On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model

被引:41
作者
Hulten, Maj A. [1 ]
Patel, Suketu [2 ]
Jonasson, Jon [3 ]
Iwarsson, Erik [4 ]
机构
[1] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
[2] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
[3] Linkoping Univ Hosp, LMC, S-58185 Linkoping, Sweden
[4] Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Clin Genet Unit, S-17176 Stockholm, Sweden
基金
英国生物技术与生命科学研究理事会; 英国惠康基金; 瑞典研究理事会;
关键词
FOLLICLE-STIMULATING-HORMONE; GERM-CELLS; MEIOTIC RECOMBINATION; GRANDMATERNAL AGE; CHROMOSOME SEGREGATION; REDUCED RECOMBINATION; CENTROMERE SEPARATION; SPINDLE CHECKPOINT; MITOTIC ERRORS; FETAL OOCYTES;
D O I
10.1530/REP-09-0088
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have recently documented that trisomy 21 mosaicism is common in human foetal ovaries. On the basis of this observation we propose that the maternal age effect in Down syndrome (DS) is caused by the differential behaviour of trisomy 21 in relation to disomy 21 oocytes during development from foetal life until ovulation in adulthood. in particular, we suggest that trisomy 21 oocytes, lagging behind those that are disomic, may escape the timed pruning of the seven million in foetal life to the 300-400 finally selected for ovulation. The net effect of this preferential elimination will be an accumulation of trisomy 21 oocytes in the ovarian reserve of older women. We here highlight the implications of this Oocyte Mosaicism Selection (OMS) model with respect to the prevalent view that the maternal age effect is complex, dependent on many different biological and environmental factors. We examine conclusions drawn from recent large-scale studies in families, tracing DNA markers along the length of chromosome 21q between parents and DS children, in comparison to the OMS model. We conclude that these family linkage data are equally compatible with the maternal age effect originating from the accumulation of trisomy 21 oocytes with advancing maternal age. One relatively straightforward way to get to grips with what is actually going on in this regard would be to compare incidence of trisomy 21 oocytes (and their pairing configurations) in foetal ovaries with that in oocytes at the meiosis I stage from adult women. Reproduction (2010) 139 1-9
引用
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页码:1 / 9
页数:9
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