Dermatomyositis with Rapidly Progressive Interstitial Lung Disease Treated with Rituximab: A Report of 3 Cases in Japan

被引：42

作者：

Tokunaga, Kenichiro ^{[1
]}

Hagino, Noboru ^{[2
]}

机构：

[1] Japanese Red Cross Kumamoto Hosp, Dept Rheumatol, Kumamoto, Japan

[2] Teikyo Univ, Chiba Med Ctr, Div Rheumatol, Tokyo, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 11期

关键词：

anti-ARS antibody; anti-MDA5; antibody; dermatomyositis; interstitial lung disease; rituximab; anti-PL-12; CLINICALLY AMYOPATHIC DERMATOMYOSITIS; THERAPY; POLYMYOSITIS; CYCLOPHOSPHAMIDE; COMPLICATION; TACROLIMUS; ANTIBODY; FERRITIN;

D O I：

10.2169/internalmedicine.56.7956

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed a retrospective chart review of three patients with hypomyopathic dermatomyositis and rapidly progressive interstitial lung disease. The patients were Japanese women of 71, 69, and 65 years of age. Two patients were anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive and 1 was anti-aminoacyl-tRNA synthetase (anti-ARS) antibody-positive. Their respiratory statuses deteriorated despite the administration of glucocorticoid, calcineurin inhibitors, and intravenous cyclophosphamide therapy. We subsequently administered rituximab. The anti-ARS antibody-positive patient survived, while 2 anti-MDA5 antibody-positive patients died.

引用

页码：1399 / 1403

页数：5

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