Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women

被引:56
作者
Basu, Rita
Dalla Man, Chiara
Campioni, Marco
Basu, Ananda
Nair, K. Sree
Jensen, Michael D.
Khosla, Sundeep
Klee, George
Toffolo, Gianna
Cobelli, Claudio
Rizza, Robert A.
机构
[1] Mayo Clin, Coll Med, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA
[2] Univ Padua, Dept Elect & Informat, Padua, Italy
[3] Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN USA
关键词
D O I
10.2337/db06-1504
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine if dehydroepiandrosterone (DHEA) replacement improves insulin secretion, insulin action, and/or postprandial glucose metabolism, 112 elderly subjects with relative DHEA deficiency ingested a labeled mixed meal and underwent a frequently sampled intravenous glucose tolerance test before and after 2 years of either DHEA or placebo. Despite restoring DHEA sulphate concentrations values observed in young men and women, the changes over time in fasting and postprandial glucose concentrations, meal appearance, glucose disposal, and endogenous glucose production were identical to those observed after 2 years of placebo. The change over time in postmeal and intravenous glucose tolerance test insulin and C-peptide concentrations did not differ in men treated with DHEA or placebo. In contrast, postmeal and intravenous glucose tolerance test change over time in insulin and C-peptide concentrations were greater (P < 0.05) in women after DHEA than after placebo. However, since DHEA tended decrease insulin action, the change over time in disposition indexes did not differ between DHEA- and placebo-treate women, indicating that the slight increase in insulin secretion was a compensatory response to a slight decrease in insulin action. We conclude that 2 years of replacement of DHEA in elderly men and women does not improve insulin secretion, insulin action, or the pattern of postprandial. glucose metabolism.
引用
收藏
页码:753 / 766
页数:14
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