TGF-β and fibrosis in different organs - molecular pathway imprints

被引：527

作者：

Pohlers, Dirk ^{[1
]}

Brenmoehl, Julia ^{[2
]}

Loeffler, Ivonne ^{[3
]}

Mueller, Cornelia K. ^{[4
]}

Leipner, Carola ^{[5
]}

Schultze-Mosgau, Stefan ^{[4
]}

Stallmach, Andreas ^{[2
]}

Kinne, Raimund W. ^{[1
]}

Wolf, Gunter ^{[3
]}

机构：

[1] Univ Jena, Expt Rheumatol Unit, Univ Hosp Jena, Waldkrankenhaus Rudolf Elle Eisenberg,Dept Orthop, Jena, Germany

[2] Univ Jena, Dept Gastroenterol Hepatol & Infect Dis, Clin Internal Med 2, Univ Hosp Jena, Jena, Germany

[3] Univ Jena, Univ Hosp Jena, Clin Internal Med 3, Jena, Germany

[4] Univ Jena, Univ Hosp Jena, Clin Oromaxillofacial Surg Plast Surg, Jena, Germany

[5] Univ Jena, Univ Hosp Jena, Anim Res Inst, Jena, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 08期

关键词：

TGF-beta; Fibrosis; Arthritis; Nephritis; Inflammatory bowel disease; Crohn's disease; Wound-healing; Myocarditis; GROWTH-FACTOR-BETA; INFLAMMATORY-BOWEL-DISEASE; EPITHELIAL-MESENCHYMAL TRANSITION; B3-INDUCED CHRONIC MYOCARDITIS; SMOOTH MUSCLE ACTIN; COLLAGEN-INDUCED ARTHRITIS; MATRIX GENE-EXPRESSION; PROXIMAL TUBULAR CELLS; FOCAL ADHESION KINASE; TUMOR-NECROSIS-FACTOR;

D O I：

10.1016/j.bbadis.2009.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The action of transforming-growth-factor (TGF)-beta following inflammatory responses is characterized by increased production of extracellular matrix (ECM) components, as well as mesenchymal cell proliferation, migration, and accumulation. Thus, TGF-beta is important for the induction of fibrosis often associated with chronic phases of inflammatory diseases. This common feature of TGF-related pathologies is observed in many different organs. Therefore, in addition to the description of the common TGF-beta-pathway, this review focuses on TGF-beta-related pathogenetic effects in different pathologies/organs, i.e., arthritis, diabetic nephropathy, colitis/Crohn's disease, radiation-induced fibrosis, and myrocarditis (including their similarities and dissimilarities). However, TGF-beta exhibits both exacerbating and ameliorating features, depending on the phase of disease and the site of action. Due to its central role in severe fibrotic diseases, TGF-beta nevertheless remains an attractive therapeutic target, if targeted locally and during the fibrotic phase of disease. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：746 / 756

页数：11

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