Synthesis of Pyrimido[6,1-a]isoquinolines by the Reaction of Thriethyl Orthoformate with Enamines of 3,3-dialkyl-1,2,3,4-tetrahydroisoquinoline series

被引：0
作者：
Mikhailovskii, A. G. [1 ]
Peretyagin, D. A. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Ul Polevaya 2, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 55卷 / 05期
关键词：
Z)-2-[3; 3-dimethyl-3; 4-dihydroisoquinolin-1(2H)-ylidene]acetamides; benzo[f]isoquinoline amides; triethyl orthoformate; 6; 6-dimethyl-6; 7-dihydro-2H-pyrimido[6; 1-ia]isoquinolin-2-ones;
D O I：
10.1134/S1070428019050233
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Boiling (Z)-2-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides in AcOEt/Ac2O leads involves annelation of the pyrimidine ring to form 6,6-dimethyl-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-2-ones. Similarly, benzo[f]isoquinoline amides form in this reaction 12,12-dialkyl-11,12-dihydro-3H-benzo[f]pyrimido[6,1-a]isoquinolin-3-ones.
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收藏
页码：721 / 723
页数：3
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