Cerebrospinal fluid markers of neuronal and glial cell damage in patients with autoimmune neurologic syndromes with and without underlying malignancies

被引：15

作者：

Constantinescu, Radu ^{[1
,7
]}

Krysl, David ^{[1
,7
]}

Andren, Kerstin ^{[1
,7
]}

Asztely, Fredrik ^{[1
,5
]}

Bergquist, Filip ^{[1
,7
]}

Zetterberg, Henrik ^{[2
,3
,4
]}

Andreasson, Ulf ^{[2
,3
]}

Axelsson, Markus ^{[1
,7
]}

Ben Menachem, Elinor ^{[1
,7
]}

Jons, Daniel ^{[1
,7
]}

Mahamud, Ubah ^{[1
,7
]}

Malmestrom, Clas ^{[1
,6
,7
]}

Rosengren, Lars ^{[1
,7
]}

Blennow, Kaj ^{[2
,3
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Molndal, Sweden

[3] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[4] UCL, Inst Neurol, Queen Sq, London WC1N 3BG, England

[5] Auckland Univ, Dept Neurol, Waikato Clinical Campus, Auckland, New Zealand

[6] Sahlgrens Univ Hosp, Clin Immunol Lab, Gothenburg, Sweden

[7] Sahlgrens Univ Hosp, Dept Neurol, S-41345 Gothenburg, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 306卷

关键词：

Autoimmune neurological syndrome; Paraneoplastic neurologic syndrome; Non-paraneoplastic; Autoimmune encephalitis; Neurofilament light chain; Tau protein; CENTRAL-NERVOUS-SYSTEM; PARANEOPLASTIC SYNDROMES; LIMBIC ENCEPHALITIS; DIAGNOSIS; ANTIBODIES; DISEASE;

D O I：

10.1016/j.jneuroim.2017.02.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune neurologic syndromes can be paraneoplastic (associated with malignancies and/or onconeural antibodies), or non-paraneoplastic Their clinical presentation is often similar. As prognosis is related to malignancy treatment, better biomarkers are needed to identify patients with malignancy. We investigated cerebrospinal fluid (CSF) markers of neuronal (neurofilament light chain, NFL and total tau protein, T-tau) and glial (glial fibrillary acidic protein) damage. CSF-NFL and T-tau were increased in both paraneoplastic and non-paraneoplastic autoimmune syndromes. Patients with manifest malignancies were older, had less epilepsy, more focal central and peripheral neurological signs and symptoms, and worse long-term outcome, than those without malignancy. CSF-NFL-levels predicted long-term outcome but were not diagnostic for malignancy, after age adjustment. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：25 / 30

页数：6

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