Short Report: Activity of Artemether and Mefloquine against Juvenile and Adult Schistosoma mansoni in Athymic and Immunocompetent NMRI Mice

被引:20
作者
Keiser, Jennifer [1 ]
Vargas, Mireille [1 ]
Doenhoff, Michael J. [2 ]
机构
[1] Swiss Trop Inst, Dept Med Parasitol & Infect Biol, CH-4002 Basel, Switzerland
[2] Univ Nottingham, Sch Biol, Nottingham NG7 2RD, England
基金
瑞士国家科学基金会;
关键词
CELL; CHEMOTHERAPY; PRAZIQUANTEL; ARTEMISININS; INFECTION;
D O I
10.4269/ajtmh.2010.09-0461
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the in vivo effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg), recently described to have promising antischistosomal properties, against juvenile and adult Schistosoma mansoni in T cell-deficient and in comparably infected age- and sex-matched immunologically intact control mice. Artemether and mefloquine are equally effective in athymic and immunocompetent mice. Artemether treatment resulted in total and female worm burden reductions ranging between 71.1% and 85.3%, whereas mefloquine achieved total and female worm burden reductions of 80.4-97.8%. In conclusion, artemether and mefloquine act T-cell independently and no synergistic interaction with the immune response was involved.
引用
收藏
页码:112 / 114
页数:3
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