Malignancies in systemic lupus erythematosus

被引：57

作者：

Kiss, Emese ^{[2
]}

Kovacs, Laszlo ^{[3
]}

Szodoray, Peter ^{[1
]}

机构：

[1] Univ Oslo, Inst Basic Med Sci, Immunobiol Lab, Oslo, Norway

[2] Natl Inst Rheumatism & Physiotherapy, Budapest, Hungary

[3] Univ Szeged, Dept Rheumatol, Szeged, Hungary

来源：

AUTOIMMUNITY REVIEWS | 2010年 / 9卷 / 04期

关键词：

Lupus; Malignancy; Pathogenesis; Genetics; EBV; Smoking; CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKINS-LYMPHOMA; B-CELLS; AUTOIMMUNE-DISEASES; CANCER; PROLIFERATION; COHORT; RISK; MANIFESTATIONS; ACTIVATION;

D O I：

10.1016/j.autrev.2009.07.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease, characterized by a wide array of symptoms and organ involvements, leading to varying disease courses and outcome, and ranging from mild to severe types. In patients with SLE, the incidence and risk of malignancy development is increased, and mostly non-Hodgkin's lymphoma (NHL), cervical cancer, as well as bronchial carcinomas Occur. Besides others, the common genetic predisposition, chronic antigen stimulus, disproportional immune responses, as well as the chronic administration of immunosuppressive medications can contribute to the development of malignancies in lupus. In this review we present the molecular pathology, as well as the epidemiological and clinical aspects of malignancies in patients with SLE. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：195 / 199

页数：5

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