Metabolism and cancer: the circadian clock connection

被引：431

作者：

Sahar, Saurabh ^{[1
]}

Sassone-Corsi, Paolo ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pharmacol, Sch Med, Irvine, CA 92697 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 12期

关键词：

DNA-DAMAGE RESPONSE; REV-ERB-ALPHA; BREAST-CANCER; GENE-EXPRESSION; CELL-DEATH; SIRT1; TRANSCRIPTION; MOUSE; PROTEIN; MUTANT;

D O I：

10.1038/nrc2747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circadian rhythms govern a remarkable variety of metabolic and physiological functions. Accumulating epidemiological and genetic evidence indicates that the disruption of circadian rhythms might be directly linked to cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of the cell cycle, and alterations in clock function could lead to aberrant cellular proliferation. In addition, connections between the circadian clock and cellular metabolism have been identified that are regulated by chromatin remodelling. This suggests that abnormal metabolism in cancer could also be a consequence of a disrupted circadian clock. Therefore, a comprehensive understanding of the molecular links that connect the circadian clock to the cell cycle and metabolism could provide therapeutic benefit against certain human neoplasias.

引用

页码：886 / 896

页数：11

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