Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat

被引：37
作者：
Firestein, Ron [1 ,2 ]
Hahn, William C. [1 ,3 ,4 ]
机构：
[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[4] Broad Inst Harvard & MIT, Cambridge, MA USA
来源：
CANCER RESEARCH | 2009年 / 69卷 / 20期
基金：
美国国家卫生研究院;
关键词：
BETA-CATENIN; MEDIATOR COMPLEX; GENE-EXPRESSION; TRANSCRIPTION; ACTIVATION; PHOSPHORYLATION; SUBCOMPLEX; PYGOPUS; MED12;
D O I：
10.1158/0008-5472.CAN-09-1704
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Wnt/beta-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of beta-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which beta-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regidates beta-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear beta-catenin activity and identify a novel therapeutic target for beta-catenin-driven malignancies. [Cancer Res 2009;69(20):7899-901]
引用
收藏
页码：7899 / 7901
页数：3
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