Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat

被引：37

作者：

Firestein, Ron ^{[1
,2
]}

Hahn, William C. ^{[1
,3
,4
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[4] Broad Inst Harvard & MIT, Cambridge, MA USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 20期

基金：

美国国家卫生研究院;

关键词：

BETA-CATENIN; MEDIATOR COMPLEX; GENE-EXPRESSION; TRANSCRIPTION; ACTIVATION; PHOSPHORYLATION; SUBCOMPLEX; PYGOPUS; MED12;

D O I：

10.1158/0008-5472.CAN-09-1704

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Wnt/beta-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of beta-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which beta-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regidates beta-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear beta-catenin activity and identify a novel therapeutic target for beta-catenin-driven malignancies. [Cancer Res 2009;69(20):7899-901]

引用

页码：7899 / 7901

页数：3

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