Copper-Catalyzed Deoxygenative C2-Sulfonylation of Quinoline N-Oxides with DABSO and Phenyldiazonium Tetrafluoroborates for the Synthesis of 2-Sulfonylquinolines via a Radical Reaction

被引：41

作者：

Li, Guang-Hui ^{[1
]}

Dong, Dao-Qing ^{[1
]}

Deng, Qi ^{[2
]}

Yan, Shi-Qiang ^{[3
]}

Wang, Zu-Li ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Shandong, Peoples R China

[2] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China

[3] Shandong Dyne Marine Biopharmaceut Co Ltd, Weihai 264300, Shandong, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 17期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

quinoline-N-oxides; DABSO; radicals; sulfonylation; copper; IODINE-MEDIATED SULFONYLATION; ONE-POT SYNTHESIS; SULFUR-DIOXIDE; INSERTION; ARYL; BOND; ARYLSULFONYLATION; DERIVATIVES; ACTIVATION; ACIDS;

D O I：

10.1055/s-0037-1611787

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical method for the synthesis of 2-sulfonylquinolines through copper-catalyzed deoxygenative C2-sulfonylation of quinoline N -oxides with 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) (DABSO) and phenyldiazonium tetrafluoroborates is demonstrated. Products with various substituents were obtained in moderate to high yields.

引用

页码：3313 / 3319

页数：7

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