Polycomb/Trithorax response elements and epigenetic memory of cell identity

被引：356
作者：
Ringrose, Leonie
Paro, Renato
机构：
[1] IMBA Inst Mol Biotechnol GmbH, A-1030 Vienna, Austria
[2] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany
来源：
DEVELOPMENT | 2007年 / 134卷 / 02期
关键词：
D O I：
10.1242/dev.02723
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal pieces. Just a few hundred base pairs long, these elements can remember and maintain the active or silent transcriptional state of their associated genes for many cell generations, long after the initial determining activators and repressors have disappeared. Recently, substantial progress has been made towards understanding the nuts and bolts of PRE/TRE function at the molecular level and in experimentally mapping PRE/TRE sites across whole genomes. Here we examine the insights, controversies and new questions that have been generated by this recent flood of data.
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页码：223 / 232
页数：10
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