Polycomb/Trithorax response elements and epigenetic memory of cell identity

被引：356
作者：
Ringrose, Leonie
Paro, Renato
机构：
[1] IMBA Inst Mol Biotechnol GmbH, A-1030 Vienna, Austria
[2] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany
来源：
DEVELOPMENT | 2007年 / 134卷 / 02期
关键词：
D O I：
10.1242/dev.02723
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal pieces. Just a few hundred base pairs long, these elements can remember and maintain the active or silent transcriptional state of their associated genes for many cell generations, long after the initial determining activators and repressors have disappeared. Recently, substantial progress has been made towards understanding the nuts and bolts of PRE/TRE function at the molecular level and in experimentally mapping PRE/TRE sites across whole genomes. Here we examine the insights, controversies and new questions that have been generated by this recent flood of data.
引用
收藏
页码：223 / 232
页数：10
相关论文
共 122 条
[1]   The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly [J].
Ahmad, K ;
Henikoff, S .
MOLECULAR CELL, 2002, 9 (06) :1191-1200
[2]   The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors [J].
Akasaka, T ;
Tsuji, K ;
Kawahira, H ;
Kanno, M ;
Harigaya, K ;
Hu, LN ;
Ebihara, Y ;
Nakahata, T ;
Tetsu, O ;
Taniguchi, M ;
Koseki, H .
IMMUNITY, 1997, 7 (01) :135-146
[3]   Cellular memory and dynamic regulation of polycomb group proteins [J].
Bantignies, F ;
Cavalli, G .
CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (03) :275-283
[4]   Function of the Trithorax-like gene during Drosophila development [J].
Bejarano, F ;
Busturia, A .
DEVELOPMENTAL BIOLOGY, 2004, 268 (02) :327-341
[5]  
Bender W, 2002, DEVELOPMENT, V129, P4923
[6]   A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].
Bernstein, BE ;
Mikkelsen, TS ;
Xie, XH ;
Kamal, M ;
Huebert, DJ ;
Cuff, J ;
Fry, B ;
Meissner, A ;
Wernig, M ;
Plath, K ;
Jaenisch, R ;
Wagschal, A ;
Feil, R ;
Schreiber, SL ;
Lander, ES .
CELL, 2006, 125 (02) :315-326
[7]  
Beuchle D, 2001, DEVELOPMENT, V128, P993
[8]   Efficient and specific targeting of polycomb group proteins requires cooperative interaction between grainyhead and pleiohomeotic [J].
Blastyák, A ;
Mishra, RK ;
Karch, F ;
Gyurkovics, H .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (04) :1434-1444
[9]   Polycomb complexes repress developmental regulators in murine embryonic stem cells [J].
Boyer, LA ;
Plath, K ;
Zeitlinger, J ;
Brambrink, T ;
Medeiros, LA ;
Lee, TI ;
Levine, SS ;
Wernig, M ;
Tajonar, A ;
Ray, MK ;
Bell, GW ;
Otte, AP ;
Vidal, M ;
Gifford, DK ;
Young, RA ;
Jaenisch, R .
NATURE, 2006, 441 (7091) :349-353
[10]   Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions [J].
Bracken, AP ;
Dietrich, N ;
Pasini, D ;
Hansen, KH ;
Helin, K .
GENES & DEVELOPMENT, 2006, 20 (09) :1123-1136
12345678910