Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

被引：159
|
作者：
Iizuka, Katsumi [2 ]
Takeda, Jun
Horikawa, Yukio [1 ,2 ]
机构：
[1] Gifu Univ, Grad Sch Med, Dept Endocrinol & Diabet, Div Mol & Struct, Gifu 5011194, Japan
[2] Gunma Univ, Inst Mol & Cellular Regulat, Lab Med Genom, Maebashi, Gunma 3718512, Japan
来源：
FEBS LETTERS | 2009年 / 583卷 / 17期
基金：
日本学术振兴会;
关键词：
Fibroblast growth factor 21; Carbohydrate response element binding protein; Rat hepatocyte; Liver type pyruvate kinase; Fatty acid synthase; FIBROBLAST GROWTH FACTOR-21; RECEPTOR-GAMMA; KLOTHO; OBESITY; FGF-21; FIBROBLAST-GROWTH-FACTOR-21; IDENTIFICATION; LIPOGENESIS; DEFICIENCY; FAMILY;
D O I：
10.1016/j.febslet.2009.07.053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2882 / 2886
页数：5
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