Molecular connectivity to find beta-blockers with low toxicity

被引：40

作者：

GarciaDomenech, R ^{[1
]}

Alapont, CD ^{[1
]}

deJulianOrtiz, JV ^{[1
]}

Galvez, J ^{[1
]}

Popa, L ^{[1
]}

机构：

[1] FAC PHARM,DEPT CHEM PHYS,BUCHAREST 70138,ROMANIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(97)00046-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Molecular connectivity has been used to find new beta-blocker drugs using linear discriminant analysis and connectivity functions with different topological descriptors. Among the selected compounds stands out the probucol and the beta-carotene. Both of them interact with beta adrenoceptors. (C) 1997 Elsevier Science Ltd.

引用

页码：567 / 572

页数：6

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