Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats

被引：59

作者：

Jia, Jun ^{[1
]}

Sun, ZuoLi ^{[1
]}

Li, Bo ^{[1
]}

Pan, YanLi ^{[2
]}

Wang, HaoMin ^{[2
]}

Wang, Xuan ^{[1
]}

Yu, Fen ^{[1
]}

Liu, LiMin ^{[1
]}

Zhang, LiJuan ^{[1
]}

Wang, XiaoMin ^{[1
,2
]}

机构：

[1] Capital Med Univ, Key Lab Neurodegenerat Disorders, Dept Physiol, Minist Educ, Beijing 100069, Peoples R China

[2] Peking Univ, Minist Educ, Neurosci Res Inst, Key Lab Neurosci, Beijing 100083, Peoples R China

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 205卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Electro-acupuncture; Substance P; GABA; Basal ganglia circuit; Parkinson's disease; MEDIAL FOREBRAIN-BUNDLE; TRANSCRANIAL MAGNETIC STIMULATION; INDUCED ROTATIONAL BEHAVIOR; SUBSTANTIA-NIGRA; BASAL GANGLIA; 6-HYDROXYDOPAMINE LESION; DOPAMINERGIC-NEURONS; FUNCTIONAL RECOVERY; TRANSECTED RATS; CELL-DEATH;

D O I：

10.1016/j.bbr.2009.06.024

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Electro-acupuncture (EA) is believed to be effective for alleviating motor symptoms in patients with Parkinson's disease. In a rat hemiparkinsonian model induced by unilateral transection of the medial forebrain bundle (MFB), the effects of EA stimulation were investigated. EA stimulation at a high frequency (100 Hz) significantly reduced apomorphine-induced rotational behavior. Tyrosine hydroxylase immunohistochemical staining revealed that EA at 100 Hz protected axotomized dopaminergic neurons from degeneration in the substantia nigra (SN). Moreover, high frequency EA reversed the axotomy-induced decrease in substance P content and increase in glutamate decarboxylase-67 (GAD 67) mRNA level in the midbrain; however, it did not affect the axotomy-induced increase in enkephalin content in the globus pallidus. These results suggest that the effects of high frequency EA on motor symptoms of Parkinsonian rats may involve restoration of the homeostasis of dopaminergic transmission in the basal ganglia circuit. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：214 / 218

页数：5

共 31 条

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