Advanced Label-Free Laser Scanning Microscopy and Its Biological Imaging Application

被引：4
|
作者：
Wang, Xue [1 ,2 ]
Lu, Xinchao [1 ]
Huang, Chengjun [1 ,2 ]
机构：
[1] Chinese Acad Sci, Hlth Elect Ctr, Inst Microelect, Beijing 100029, Peoples R China
[2] Univ Chinese Acad Sci, Sch Microelect, Beijing 100049, Peoples R China
来源：
APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 03期
基金：
北京市自然科学基金;
关键词：
laser scanning microscopy; label-free; coherent anti-Stokes Raman scattering; stimulated Raman scattering; second harmonic generation; surface plasmon polaritons;
D O I：
10.3390/app11031002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
By eliminating the photodamage and photobleaching induced by high intensity laser and fluorescent molecular, the label-free laser scanning microscopy shows powerful capability for imaging and dynamic tracing to biological tissues and cells. In this review, three types of label-free laser scanning microscopies: laser scanning coherent Raman scattering microscopy, second harmonic generation microscopy and scanning localized surface plasmon microscopy are discussed with their fundamentals, features and recent progress. The applications of label-free biological imaging of these laser scanning microscopies are also introduced. Finally, the performance of the microscopies is compared and the limitation and perspectives are summarized.
引用
收藏
页码：1 / 18
页数：18
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