Liver Tissue Engineering: Challenges and Opportunities

被引：65

作者：

Agarwal, Tarun ^{[1
]}

Subramanian, Bhuvaneshwaran ^{[2
]}

Maiti, Tapas Kumar ^{[1
]}

机构：

[1] Indian Inst Technol Kharagpur, Dept Biotechnol, Kharagpur 721302, W Bengal, India

[2] Indian Inst Technol Kharagpur, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2019年 / 5卷 / 09期

关键词：

liver; tissue engineering; matrix; biomaterials; biliary network; vasculature; scaffold; BILIARY EPITHELIAL-CELLS; PLURIPOTENT STEM-CELLS; SINUSOIDAL ENDOTHELIAL-CELLS; PHENOTYPE IN-VITRO; EXTRACELLULAR-MATRIX; HEPATOCYTE FUNCTION; HEPATIC TISSUE; SUBSTRATE STIFFNESS; HYDROGEL PLATFORM; PROGENITOR CELLS;

D O I：

10.1021/acsbiomaterials.9b00745

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Liver tissue engineering aims at the possibility of reproducing a fully functional organ for the treatment of acute and chronic liver disorders. Approaches in this field endeavor to replace organ transplantation (gold standard treatment for liver diseases in a clinical setting) with in vitro developed liver tissue constructs. However, the complexity of the liver microarchitecture and functionality along with the limited supply of cellular components of the liver pose numerous challenges. This review provides a comprehensive outlook onto how the physicochemical, mechano-biological, and spatiotemporal aspects of the substrates could be tuned to address current challenges in the field. We also highlight the strategic advancements made in the field so far for the development of artificial liver tissue. We further showcase the currently available prototypes in research and clinical trials, which shows the hope for the future of liver tissue engineering.

引用

页码：4167 / 4182

页数：31

共 156 条

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