New three-component cyclocondensation reaction:: microwave-assisted one-pot synthesis of 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

被引：76
|
作者：
Liang, Bing
Wang, Xitian
Wang, Jin-Xian
Du, Zhengyin
机构：
[1] NW Normal Univ, Dept Chem, Inst Chem, Lanzhou 730070, Gansu, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
TETRAHEDRON | 2007年 / 63卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Biginelli reactions; solvent-free; microwave-assisted; one-pot; 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones; zinc iodide;
D O I：
10.1016/j.tet.2006.12.062
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sixteen 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones have been synthesized by microwave-assisted Biginelli reactions in a short and concise manner employing ZnI2 as a catalyst under solvent-free conditions. All products were identified by IR, NMR, elemental analysis and HRMS. The advantages of this novel protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and expensive catalysts. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1981 / 1986
页数：6
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