Evaluation of Anticancer Activity of Schiff bases Derived from Pyridine and their Metal Complexes (A Review)

被引：3

作者：

Induleka, R. ^{[1
]}

Chandrika, P. Anushyaveera ^{[1
]}

Tamilselvi, M. ^{[1
]}

Ushanandhini, S. ^{[1
]}

Gowri, M. ^{[1
]}

机构：

[1] Avinashilingam Inst Home Sci & Higher Educ Women, Dept Chem, Coimbatore 641043, Tamil Nadu, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2022年 / 38卷 / 03期

关键词：

Pyridine; Metal complexes; Anti cancer activity; Cell viability; IC50; SPECTRAL CHARACTERIZATION; SONOCHEMICAL SYNTHESIS; DFT CALCULATIONS; CD(II); LIGAND; CU(II); ZN(II); NI(II); CO(II); FE(II);

D O I：

10.13005/ojc/380302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a deadly disease; many treatment strategies are available to cure/treat cancer. After the metal-based anticancer drug (Cisplatin), metal complexes play a vital role in pharmaceutical science. We aimed to analyze the anticancer activity of pyridine Schiff base complexes. This review article searched the anticancer studies of pyridine Schiff base metal complexes from 2015 to 2021. Information was gathered from the selected studies to analyze and highlight the importance of anticancer agents. A total of sixty six full-length articles were collected and evaluated. On the critical assessment, we found that compared to Schiff base ligand, the metal complexes exhibited excellent activity towards various cancer cell lines (including MCF-7, HeLa, HCT-116, Hepa-2). We identified more complexes that exhibited promising activity against various cell lines and revealed IC50 values equal to or even lower than the reference drug used.

引用

页码：517 / 536

页数：20

共 50 条

[21] Analytical and Crystallographic Parameters of Cd(II) Complexes Derived from Substituted Schiff Bases
Turwatkar, S. L.
Mehta, B. H.
ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (09) : 6962 - 6968
[22] DNA interactions and biocidal activity of metal complexes of benzothiazole Schiff bases: synthesis, characterization and validation
Vamsikrishna, Narendrula
Kumar, Marri Pradeep
Ramesh, Gali
Ganji, Nirmala
Daravath, Sreenu
Shivaraj
JOURNAL OF CHEMICAL SCIENCES, 2017, 129 (05) : 609 - 622
[23] Microbial activity of some heterocyclic Schiff bases and metal complexes: A review
Fonkui, Thierry Y.
Ikhile, Monisola I.
Ndinteh, Derek T.
Njobeh, Patrick B.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (12) : 2507 - 2518
[24] Synthesis, Characterization and Antimicrobial Activity of First Row Transition Metal(II) Complexes of Novel Schiff Base Derived from Sulfapyridine and Pyridine-2-Aldehyde
Rama, I.
Usha, V.
ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (06) : 3225 - 3228
[25] Synthesis, characterization and antibacterial properties of Schiff bases and Schiff base metal complexes derived from 2,3-diamino- pyridine
Tagenine Jeewoth
Minu G. Bhowon
Henri Li Kam Wah
Transition Metal Chemistry, 1999, 24 : 445 - 448
[26] Metal complexes of Schiff bases derived from dicinnamoylmethane and aliphatic diamines
Krishnankutty, K.
Sayudevi, P.
Ummathur, Muhammed Basheer
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2008, 73 (04) : 423 - 429
[27] Metal Complexes Derived from 2′-hydroxyacetophenone Based Schiff base: (A-Review)
Gupta, Pallavee
Dwivedi, Dhananjay
Chourey, Vijay R.
ORIENTAL JOURNAL OF CHEMISTRY, 2021, 37 (01) : 25 - 32
[28] Pharmacological aspects of schiff base metal complexes: A critical review
Ashraf, Tuba
Ali, Bakhat
Qayyum, Hasnain
Haroone, Muhammad Sohail
Shabbir, Ghulam
INORGANIC CHEMISTRY COMMUNICATIONS, 2023, 150
[29] Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies
Karabasannavar, Shambuling
Allolli, Parvati
Shaikh, Irfan N.
Kalshetty, Basavaraj M.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2017, 51 (03) : 490 - 501
[30] Schiff Bases and Complexes: A Review on Anti-Cancer Activity
Matela, Garima
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (16) : 1908 - 1917

← 1 2 3 4 5 →