Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

被引：4

作者：

Krasnyuk, I. I., Jr. ^{[1
]}

Kosheleva, T. M. ^{[1
]}

Belyatskaya, A. V. ^{[1
]}

Krasnyuk, I. I. ^{[1
]}

Stepanova, O. I. ^{[1
]}

Skovpen, Yu. ^{[2
]}

Grikh, V. V. ^{[1
]}

Ovsyannikova, L. V. ^{[1
]}

机构：

[1] IM Sechenov First Moscow State Med Univ, 8-2 Trubetskaya St, Moscow 119991, Russia

[2] Rancho BioSci, 16955 Via Del Campo Suite 220, San Diego, CA 92127 USA

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 03期

关键词：

indomethacin; solid dispersions; polyethylene glycol 1500; solubility; crystallinity;

D O I：

10.1007/s11094-018-1799-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 - 2.2 and 3.1 - 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.

引用

页码：241 / 244

页数：4

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