A Bioconjugated Chlorin-Based Metal-Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers

被引：26

作者：

Sakamaki, Yoshie ^{[1
]}

Ozdemir, John ^{[1
]}

Heidrick, Zachary ^{[1
]}

Azzun, Anthony ^{[1
]}

Watson, Olivia ^{[1
]}

Tsuji, Miu ^{[1
]}

Salmon, Christopher ^{[1
]}

Sinha, Arvind ^{[2
,3
]}

Batta-Mpouma, Joseph ^{[2
,3
]}

McConnell, Zachary ^{[1
]}

Fugitt, David ^{[1
]}

Du, Yuchun ^{[4
]}

Kim, Jin-Woo ^{[2
,3
]}

Beyzavi, Hudson ^{[1
]}

机构：

[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

[2] Univ Arkansas, Dept Biol & Agr Engn, Fayetteville, AR 72701 USA

[3] Univ Arkansas, Inst Nanosci & Engn, Fayetteville, AR 72701 USA

[4] Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA

来源：

ACS APPLIED BIO MATERIALS | 2021年 / 4卷 / 02期

基金：

美国国家科学基金会;

关键词：

photodynamic therapy; metal-organic framework; drug delivery system; pancreatic cancer; triple negative breast cancer; PORPHYRIN; ZIRCONIUM; PHOTOSENSITIZERS; PHTHALOCYANINES; NANOPARTICLES; AGGREGATION;

D O I：

10.1021/acsabm.0c01324

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The field of photodynamic therapy (PDT) has continued to show promise as a potential method for treating tumors. In this work, a photosensitizer (PS) has been delivered to cancer cell lines for PDT by incorporation into the metal-organic framework (MOF) as an organic linker. By functionalizing the surface of MOF nanoparticles with maltotriose, the PS can efficiently target cancer cells with preferential uptake into pancreatic and breast cancer cell lines. Effective targeting overcomes some current problems with PDT including long-term photosensitivity and tumor specificity. Developing a PS with optimal absorption and stability is one of the foremost challenges in PDT, and the synthesis of a chlorin, which is activated by long wavelength light and is resistant to photobleaching, is described. This chlorin-based MOF shows anticancer ability several times higher than that of porphyrin-based MOFs with little toxicity to normal cell lines and no dark toxicity.

引用

页码：1432 / 1440

页数：9

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