Pleomorphic angioleiomyoma - Report of two cases with immunohistochemical studies

被引:15
作者
Kawagishi, N
Kashiwagi, T
Ibe, M
Manabe, A
Ishida-Yamamoto, A
Hashimoto, Y
Iizuka, H
机构
[1] Kitami Kobayashi Hosp, Div Dermatol, Kitami, Hokkaido 0900043, Japan
[2] Asahikawa Med Coll, Dept Dermatol, Asahikawa, Hokkaido 078, Japan
关键词
pleomorphic tumor; angioleiomyoma; nuclear pleomorphism; PCNA;
D O I
10.1097/00000372-200006000-00012
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
We describe two cases of pleomorphic angioleiomyoma. In one case, a 46-year-old man presented with a single nodule on his scrotum of 1 year's duration, and in another, a 38-year-old woman presented with a single nodule on her right knee of I year's duration. In both cases, histopathologic examination showed a well-circumscribed nodule composed of smooth muscle and numerous veins and capillaries. Contrary to the ordinary angioleiomyoma, marked nuclear pleomorphism was noted. Although mitoses were rare, immunohistochemistry revealed many tumor cells that were positive for proliferating cell nuclear antigen, Ki-67, and p53, indicating that the pleomorphic appearance does not simply represent a degenerative change of some tumor cells.
引用
收藏
页码:268 / 271
页数:4
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