A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction

被引：25

作者：

Chiba, Tsutomu ^{[1
]}

Marusawa, Hiroyuki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sakyo Ku, Kyoto 6068507, Japan

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2009年 / 87卷 / 10期

关键词：

Activation-induced cytidine deaminase (AID); Inflammation; Carcinogenesis; Helicobacter pylori; Gene mutation; HELICOBACTER-PYLORI INFECTION; KAPPA-B ACTIVATION; GASTRIC-CANCER; COLORECTAL CANCERS; HUMAN HEPATOCYTES; C-MYC; EXPRESSION; CELLS; DNA; HEPATOCARCINOGENESIS;

D O I：

10.1007/s00109-009-0527-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Inflammation is a risk for cancer development; however, its mechanism is unknown. Recent studies have revealed that activation-induced cytidine deaminase (AID), which plays essential roles in both class-switch recombination and somatic hypermutation of immunoglobulin gene in B lymphocytes, is aberrantly expressed in non-lymphoid cells not only by H.pylori and HCV infection but also by various proinflammatory cytokines, leading to the generation of gene mutations. These findings not only suggested a new mechanism of inflammation-associated carcinogenesis but has also opened up a new field of tumor biology.

引用

页码：1023 / 1027

页数：5

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