The evolving landscape of immunotherapy in solid tumors

被引：22

作者：

Keilson, Jessica M. ^{[1
]}

Knochelmann, Hannah M. ^{[1
,2
,3
]}

Paulos, Chrystal M. ^{[1
,2
]}

Kudchadkar, Ragini R. ^{[4
]}

Lowe, Michael C. ^{[1
]}

机构：

[1] Emory Univ, Winship Canc Inst, Div Surg Oncol, Dept Surg, 1365B Clifton Rd NE,Bldg B,Suite 4100, Atlanta, GA 30322 USA

[2] Emory Univ, Winship Canc Inst, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[3] Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA

[4] Winship Canc Inst, Dept Hematol & Oncol, Atlanta, GA USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2021年 / 123卷 / 03期

关键词：

cancer; immunotherapy; solid tumors; tumor immunology;

D O I：

10.1002/jso.26416

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

While surgical resection, local and cytotoxic therapies have long formed the basis of cancer care, immunotherapy now plays a key role in supplementing and even replacing these agents in the first line. Here we review the early success of programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 blockade and discuss biomarkers of therapeutic response. We next highlight a select group of novel targets in Phase III trials both as monotherapies and in combination with PD-1 inhibitors. Finally, we discuss innovations which seek to improve outcomes in therapy-resistant solid tumors.

引用

页码：798 / 806

页数：9

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