A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity

被引：101

作者：

Griffith, Darren ^{[1
]}

Morgan, Maria P. ^{[2
]}

Marmion, Celine J. ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

[2] Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin 2, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 44期

基金：

爱尔兰科学基金会;

关键词：

CRYSTAL-STRUCTURE; HYDROXAMIC ACIDS; HUMAN HDAC8; COMPLEXES; CARBOPLATIN; HYDROLYSIS; CANCER; LIGANDS;

D O I：

10.1039/b916715c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.

引用

页码：6735 / 6737

页数：3

共 25 条

[1] Anticancer activities of histone deacetylase inhibitors [J].

Bolden, Jessica E. ;

Peart, Melissa J. ;

Johnstone, Ricky W. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (09) :769-784

[2] Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer [J].

Botrugno, Oronza Antonietta ;

Santoro, Fabio ;

Minucci, Saverio .

CANCER LETTERS, 2009, 280 (02) :134-144

[3] New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer [J].

Cang, Shundong ;

Ma, Yuehua ;

Liu, Delong .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2009, 2

[4] Traversing the coordination chemistry and chemical biology of hydroxamic acids [J].

Codd, Rachel .

COORDINATION CHEMISTRY REVIEWS, 2008, 252 (12-14) :1387-1408

[5] Histone deacetylase inhibitors selectively suppress expression of HDAC7 [J].

Dokmanovic, Milos ;

Perez, Gisela ;

Xu, Weisheng ;

Ngo, Lang ;

Clarke, Cathy ;

Parmigiani, Raphael B. ;

Marks, Paul A. .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (09) :2525-2534

[6]

Fox KR., 1997, DRUG DNA INTERACTION

[7] Update of the preclinical situation of anticancer platinum complexes: Novel design strategies and innovative analytical approaches [J].

Galanski, M ;

Jakupec, MA ;

Keppler, BK .

CURRENT MEDICINAL CHEMISTRY, 2005, 12 (18) :2075-2094

[8] Novel platinum(II) ammine hydroxamate and hydroximate complexes and the platinum-assisted hydrolysis of hydroxamic acids [J].

Griffith, D ;

Lyssenko, K ;

Jensen, P ;

Kruger, PE ;

Marmion, CJ .

DALTON TRANSACTIONS, 2005, (05) :956-961

[9] Novel platinum pyridinehydroxamic acid complexes:: Synthesis, characterisation, X-ray crystallographic study and nitric oxide related properties [J].

Griffith, Darren ;

Bergamo, Alberta ;

Pin, Sara ;

Vadori, Marta ;

Mueller-Bunz, Helge ;

Sava, Gianni ;

Marmion, Celine J. .

POLYHEDRON, 2007, 26 (16) :4697-4706

[10] Reactions of platinum(II) anticancer drugs. Kinetics of acid hydrolysis of cis-diammine(cyclobutane-1,1-dicarboxylato)platinum(II) "Carboplatin" [J].

Hay, RW ;

Miller, S .

POLYHEDRON, 1998, 17 (13-14) :2337-2343

← 1 2 3 →