Role of Microglia in Age-Related Changes to the Nervous System

被引：36
作者：
Brown, David R. [1 ]
机构：
[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
来源：
THESCIENTIFICWORLDJOURNAL | 2009年 / 9卷
关键词：
prion; amyloid; neurodegeneration; iron; microglia; neuron; LIPOPOLYSACCHARIDE-INDUCED NEUROTOXICITY; ACTIVATED PROTEIN-KINASE; TRANSCRIPTION FACTOR-A; NECROSIS-FACTOR-ALPHA; AMYLOID-BETA-PROTEIN; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; PRION PROTEIN; NITRIC-OXIDE; ANTIINFLAMMATORY DRUGS;
D O I：
10.1100/tsw.2009.111
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Microglia play a curious role in the nervous system. Their role is intrinsically protective and supportive, but during neurodegenerative disease, it is well established that microglia play a significant role in the initiation of neuronal death. Microglia, like neurons, show age-related changes that could potentially alter their behavior. While extreme changes to a large population of microglia cause dramatic neuronal loss in neurodegeneration, during normal aging, subtle changes not unlike those seen in the disease state could potentially contribute to a more gradual neuronal loss that could contribute to the cognitive decline seen in the aging population. This review provides illustrations of what is known about the role of microglia in neurodegeneration and makes suggestions about the role of microglia in age-related changes to the brain.
引用
收藏
页码：1061 / 1071
页数：11
相关论文
共 92 条
[1]   Release of iron from ferritin by metabolites of benzene and superoxide radical generating agents [J].
Agrawal, R ;
Sharma, PK ;
Rao, GS .
TOXICOLOGY, 2001, 168 (03) :223-230
[2]   Inflammation and Alzheimer's disease [J].
Akiyama, H ;
Barger, S ;
Barnum, S ;
Bradt, B ;
Bauer, J ;
Cole, GM ;
Cooper, NR ;
Eikelenboom, P ;
Emmerling, M ;
Fiebich, BL ;
Finch, CE ;
Frautschy, S ;
Griffin, WST ;
Hampel, H ;
Hull, M ;
Landreth, G ;
Lue, LF ;
Mrak, R ;
Mackenzie, IR ;
McGeer, PL ;
O'Banion, MK ;
Pachter, J ;
Pasinetti, G ;
Plata-Salaman, C ;
Rogers, J ;
Rydel, R ;
Shen, Y ;
Streit, W ;
Strohmeyer, R ;
Tooyoma, I ;
Van Muiswinkel, FL ;
Veerhuis, R ;
Walker, D ;
Webster, S ;
Wegrzyniak, B ;
Wenk, G ;
Wyss-Coray, T .
NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421
[3]  
Bamberger ME, 2003, J NEUROSCI, V23, P2665
[4]   The peripheral benzodiazepine binding site in the brain in multiple sclerosis -: Quantitative in vivo imaging of microglia as a measure of disease activity [J].
Banati, RB ;
Newcombe, J ;
Gunn, RN ;
Cagnin, A ;
Turkheimer, F ;
Heppner, F ;
Price, G ;
Wegner, F ;
Giovannoni, G ;
Miller, DH ;
Perkin, GD ;
Smith, T ;
Hewson, AK ;
Bydder, G ;
Kreutzberg, GW ;
Jones, T ;
Cuzner, ML ;
Myers, R .
BRAIN, 2000, 123 :2321-2337
[5]   Brain ferritin iron may influence age- and gender-related risks of neurodegeneration [J].
Bartzokis, George ;
Tishler, Todd A. ;
Lu, Po H. ;
Villablanca, Pablo ;
Altshuler, Lori L. ;
Carter, Michele ;
Huang, Danny ;
Edwards, Nancy ;
Mintz, Jim .
NEUROBIOLOGY OF AGING, 2007, 28 (03) :414-423
[6]   Killing of prion-damaged neurones by microglia [J].
Bate, C ;
Reid, S ;
Williams, A .
NEUROREPORT, 2001, 12 (11) :2589-2594
[7]   Prostaglandin D2 mediates neuronal damage by amyloid-β or prions which activates microglial cells [J].
Bate, C ;
Kempster, S ;
Williams, A .
NEUROPHARMACOLOGY, 2006, 50 (02) :229-237
[8]   Microglia kill amyloid-β1-42 damaged neurons by a CD14-dependent process [J].
Bate, C ;
Veerhuis, R ;
Eikelenboom, P ;
Williarns, A .
NEUROREPORT, 2004, 15 (09) :1427-1430
[9]   Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].
Betarbet, R ;
Sherer, TB ;
MacKenzie, G ;
Garcia-Osuna, M ;
Panov, AV ;
Greenamyre, JT .
NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306
[10]   IRON MOBILIZATION FROM FERRITIN BY SUPEROXIDE DERIVED FROM STIMULATED POLYMORPHONUCLEAR LEUKOCYTES - POSSIBLE MECHANISM IN INFLAMMATION DISEASES [J].
BIEMOND, P ;
VANEIJK, HG ;
SWAAK, AJG ;
KOSTER, JF .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (06) :1576-1579
12345678910