The stimulation of thrombosis by hypoxia

被引：270

作者：

Gupta, Neha ^{[1
]}

Zhao, You-Yang ^{[2
,3
,4
,5
,6
]}

Evans, Colin E. ^{[2
,3
]}

机构：

[1] Jamia Millia Islamia, Fac Nat Sci, Dept Biosci, New Delhi, India

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Program Lung & Vasc Biol, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Pediat, Div Crit Care, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Northwestern Univ, Feinberg Cardiovasc Res Inst, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

THROMBOSIS RESEARCH | 2019年 / 181卷

关键词：

Hypoxia; Hypoxia-inducible factor; Thrombosis; Thrombus formation; DEEP-VEIN THROMBOSIS; FACTOR PATHWAY INHIBITOR; VENOUS THROMBOEMBOLISM; TISSUE FACTOR; HIGH-ALTITUDE; ORAL ANTICOAGULANTS; PULMONARY-EMBOLISM; INDUCIBLE FACTOR-1; PAI-1; EXPRESSION; UP-REGULATION;

D O I：

10.1016/j.thromres.2019.07.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current therapies for thrombosis do not directly target hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes include several factors that regulate thrombus formation. In this article, we review the HIF-dependent and HIF-independent signaling pathways that regulate thrombus formation under hypoxic conditions. A better understanding of hypoxia-induced thrombus formation could lead to the development of novel prophylactic therapies for thrombosis.

引用

页码：77 / 83

页数：7

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