Catching a wave: the oscillator and wavefront that create the zebrafish somite

被引:40
作者
Holley, SA
Takeda, H
机构
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[2] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan
关键词
her; delta; notch; fgf; fss/tbx24;
D O I
10.1016/S1084952102001015
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Segmentation of the paraxial mesoderm is governed by an oscillator mechanism that creates a dynamic prepattern within the caudal presomitic mesoderm. The oscillator is comprised of genetic circuit involving the Notch signaling pathway and its target genes her1 and her7. The stabilization of the oscillating prepattern is antagonized by a gradient of Fgf signaling which is highest in the caudal presomitic mesoderm. Once the level of Fgf signaling declines in the rostral presomitic mesoderm, a wavefront mediated by the transcription factor fss/tbx24, stabilizes the prepattern and leads to the segmental expression of a number of genes which then establish segment polarity and initiate morphological somite formation.
引用
收藏
页码:481 / 488
页数:8
相关论文
共 45 条
[1]   Notch signaling: Cell fate control and signal integration in development [J].
Artavanis-Tsakonas, S ;
Rand, MD ;
Lake, RJ .
SCIENCE, 1999, 284 (5415) :770-776
[2]   Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation [J].
Aulehla, A ;
Johnson, RL .
DEVELOPMENTAL BIOLOGY, 1999, 207 (01) :49-61
[3]   Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse [J].
Barrantes, ID ;
Elia, AJ ;
Wünsch, K ;
De Angelis, MH ;
Mak, TW ;
Rossant, J ;
Conlon, RA ;
Gossler, A ;
de la Pompa, JL .
CURRENT BIOLOGY, 1999, 9 (09) :470-480
[4]   Dynamic expression and essential functions of Hes7 in somite segmentation [J].
Bessho, Y ;
Sakata, R ;
Komatsu, S ;
Shiota, K ;
Yamada, S ;
Kageyama, R .
GENES & DEVELOPMENT, 2001, 15 (20) :2642-2647
[5]   A ZEBRAFISH HOMOLOG OF THE DROSOPHILA NEUROGENIC GENE NOTCH AND ITS PATTERN OF TRANSCRIPTION DURING EARLY EMBRYOGENESIS [J].
BIERKAMP, C ;
CAMPOSORTEGA, JA .
MECHANISMS OF DEVELOPMENT, 1993, 43 (2-3) :87-100
[6]  
CONLON RA, 1995, DEVELOPMENT, V121, P1533
[7]   A gene that resuscitates a theory - somitogenesis and a molecular oscillator [J].
Cooke, J .
TRENDS IN GENETICS, 1998, 14 (03) :85-88
[8]   CLOCK AND WAVEFRONT MODEL FOR CONTROL OF NUMBER OF REPEATED STRUCTURES DURING ANIMAL MORPHOGENESIS [J].
COOKE, J ;
ZEEMAN, EC .
JOURNAL OF THEORETICAL BIOLOGY, 1976, 58 (02) :455-476
[9]   Maintenance of somite borders in mice requires the Delta homologue DII1 [J].
deAngelis, MH ;
McIntyre, J ;
Gossler, A .
NATURE, 1997, 386 (6626) :717-721
[10]   Overexpression of a zebrafish homologue of the Drosophila neurogenic gene Delta perturbs differentiation of primary neurons and somite development [J].
Dornseifer, P ;
Takke, C ;
CamposOrtega, JA .
MECHANISMS OF DEVELOPMENT, 1997, 63 (02) :159-171