Review: Ewing Sarcoma Predisposition

被引：17

作者：

Gargallo, Pablo ^{[1
]}

Yanez, Yania ^{[1
]}

Juan, Antonio ^{[2
]}

Segura, Vanessa ^{[1
]}

Balaguer, Julia ^{[2
]}

Torres, Barbara ^{[2
]}

Oltra, Silves ^{[3
,4
]}

Castel, Victoria ^{[2
]}

Canete, Adela ^{[2
]}

机构：

[1] La Fe Hosp, Clin & Translat Oncol Res Grp, Av Fernando Abril Martorell 106, Valencia 46026, Spain

[2] La Fe Hosp, Pediat Oncol & Hematol Unit, Valencia, Spain

[3] La Fe Hosp, Genet Unit, Valencia, Spain

[4] Univ Valencia, Genet Dept, Valencia, Spain

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2020年 / 26卷 / 04期

关键词：

Ewing sarcoma; Cancer predisposition; Genetic susceptibility; Polymorphism; SYNDROMES CLINICAL-FEATURES; MISMATCH REPAIR DEFICIENCY; LI-FRAUMENI-SYNDROME; EPIGENETIC TRANSGENERATIONAL INHERITANCE; PEDIATRIC CANCER PREDISPOSITION; MULTIPLE ENDOCRINE NEOPLASIA; TP53 MUTATION CARRIERS; SOFT-TISSUE SARCOMAS; SURVEILLANCE RECOMMENDATIONS; MOLECULAR PATHOGENESIS;

D O I：

10.1007/s12253-019-00765-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ewing sarcoma is a rare tumor developed in bone and soft tissues of children and teenagers. This entity is biologically led by a chromosomal translocation, typically including EWS and FLI1 genes. Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among cancer predisposition syndromes has also been thoroughly examined. This review summarizes the available evidence on predisposing factors involved in Ewing sarcoma susceptibility. On the basis of these data, an integrated approach of the most influential factors on Ewing sarcoma predisposition is proposed.

引用

页码：2057 / 2066

页数：10

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