Leu-enkephalin induced by IL-2 administration mediates analgesic effect of IL-2

被引：7
|
作者：
Jiang, CL
You, ZD
Lu, CL
Xu, D
Wang, AJ
Wang, YX
Liu, XY
机构：
[1] Second Mil Med Univ, Dept Neurobiol, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biochem, Shanghai 200031, Peoples R China
来源：
NEUROREPORT | 2000年 / 11卷 / 07期
关键词：
interleukin-2; analgesic effect; Leu-enkephalin; neuroimmunomodulation; nuclei; opioid receptors; pain threshold;
D O I：
10.1097/00001756-200005150-00024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interleukin-2 (IL-2) was found to have an analgesic effect in both central and peripheral nervous systems. This effect is related to opioid receptors and mediated mainly by IL-2 directly binding to opioid receptors. Using radioimmunoassay, the content of Leu-enkephalin (LEK) in some nuclei were measured at intervals after the injection of IL-2 into the lateral ventricle of rats. Levels of LEK increased in both paraventricular hypothalamic nucleus (PVN) and locus ceruleus (LOC) after IL-2 administration, suggesting that the analgesic effect of IL-2 is also related to the change of LEK in PVN and LOC induced by IL-2 administration. NeuroReport 11:1483-1485 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：1483 / 1485
页数：3
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