From the hierarchical organization of the central nervous system to the hierarchical aspects of biocodes

被引:2
作者
Guidolin, D. [1 ]
Marcoli, M. [2 ]
Tortorella, C. [1 ]
Maura, G. [2 ]
Agnati, L. F. [3 ,4 ]
机构
[1] Univ Padua, Sect Anat, Dept Neurosci, Via Gabelli 65, I-35121 Padua, Italy
[2] Univ Genoa, Sect Pharmacol & Toxicol, Dept Pharm, Viale Cembrano 4, I-16148 Genoa, Italy
[3] Univ Modena & Reggio Emilia, Dept Diagnost Clin Med & Publ Hlth, Via Campi 287, I-41125 Modena, Italy
[4] Karolinska Inst, Dept Neurosci, Retzius Vag 8, Stockholm, Sweden
关键词
Cell networks; Neurodynamics; Biocoding; Cognition; VOLUME TRANSMISSION; BRAIN ACTIONS; COMMUNICATION; ASTROCYTES; CONSCIOUSNESS; PLASTICITY; EXPERIENCE; PHYSIOLOGY; NEOCORTEX; RELEVANCE;
D O I
10.1016/j.biosystems.2019.103975
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The quite recent (at least on the evolutionary time scale) emergence of nervous systems in complex organisms enabled the living beings to build a wide-ranging model of the external world in order to predict and evaluate the outcomes of their actions. Such a process likely represents a real coding activity, since, by proper handling of information, it generates a mapping between the external environment and internal cerebral activity patterns. The patterns of neural activity that correspond to the final maps, however, emerge from the holistic assembly of a multilevel functional organization. Nerve tissue components, indeed, appear organized in compartments, also called functional modules (FM), that contain system components and circuits of different miniaturizations not only arranged to work together either in parallel or in series but also nested within each other. At least three levels can be recognized in a functional module and it is possible to point out that such a hierarchical organization of the brain circuits could be mirrored by a corresponding hierarchical organization of biocodes. This feature can also suggest the hypothesis that the same logic could operate also at system level to integrate FM into functional brain areas and to associate areas to generate the final map used by humans to image the external world and to imagine untestable worlds.
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页数:6
相关论文
共 62 条
[1]   The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathology [J].
Agnati, L. F. ;
Guidolin, D. ;
Fuxe, K. .
JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (01) :3-19
[2]   The brain as a "hyper-network": the key role of neural networks as main producers of the integrated brain actions especially via the "broadcasted" neuroconnectomics [J].
Agnati, Luigi F. ;
Marcoli, Manuela ;
Maura, Guido ;
Woods, Amina ;
Guidolin, Diego .
JOURNAL OF NEURAL TRANSMISSION, 2018, 125 (06) :883-897
[3]   Functional roles of three cues that provide nonsynaptic modes of communication in the brain: electromagnetic field, oxygen, and carbon dioxide [J].
Agnati, Luigi F. ;
Guidolin, Diego ;
Maura, Guido ;
Marcoli, Manuela .
JOURNAL OF NEUROPHYSIOLOGY, 2018, 119 (01) :356-368
[4]   The multi-facet aspects of cell sentience and their relevance for the integrative brain actions: role of membrane protein energy landscape [J].
Agnati, Luigi F. ;
Marcoli, Manuela ;
Maura, Guido ;
Fuxe, Kjell ;
Guidolin, Diego .
REVIEWS IN THE NEUROSCIENCES, 2016, 27 (04) :347-363
[5]   The neurobiology of imagination: possible role of interaction-dominant dynamics and default mode network [J].
Agnati, Luigi F. ;
Guidolin, Diego ;
Battistin, L. ;
Pagnoni, G. ;
Fuxe, K. .
FRONTIERS IN PSYCHOLOGY, 2013, 4
[6]   Understanding wiring and volume transmission [J].
Agnati, Luigi F. ;
Guidolin, Diego ;
Guescini, Michele ;
Genedani, Susanna ;
Fuxe, Kjell .
BRAIN RESEARCH REVIEWS, 2010, 64 (01) :137-159
[7]   Neuronal correlates to consciousness. The "Hall of Mirrors" metaphor describing consciousness as an epiphenomenon of multiple dynamic mosaics of cortical functional modules [J].
Agnati, Luigi Francesco ;
Guidolin, Diego ;
Cortelli, Pietro ;
Genedani, Susanna ;
Cela-Conde, Camilo ;
Fuxe, Kjell .
BRAIN RESEARCH, 2012, 1476 :3-21
[8]  
[Anonymous], 2017, NEUROL PSYCHIAT BRAI, DOI DOI 10.1016/J.NPBR.2016.12.002
[9]  
[Anonymous], 2010, SELF COMES MIND CONS
[10]  
[Anonymous], MICROCIRCUITS INTERF