GABAA receptor antagonists enhance cortical acetylcholine release induced by 5-HT3 receptor blockade in freely moving rats

被引：32

作者：

Diez-Ariza, M ^{[1
]}

García-Alloza, M ^{[1
]}

Lasheras, B ^{[1
]}

Del Río, J ^{[1
]}

Ramírez, MJ ^{[1
]}

机构：

[1] Univ Navarra, Sch Med, Dept Pharmacol, Pamplona 31008, Spain

来源：

BRAIN RESEARCH | 2002年 / 956卷 / 01期

关键词：

acetylcholine release; serotonin; ondansetron; GABA(A) receptor antagonist; microdialysis;

D O I：

10.1016/S0006-8993(02)03483-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ACh release from the rat frontal cortex was increased by both local, 0.1-1 muM, and systemic, 0.1-10 mug/kg, administration of the 5-HT3 receptor antagonist ondansetron, reaching a maximum peak of 143% over basal values. Bicuculline, 1-10 muM, and flumazenil, 5-10 mg/kg, antagonists at different sites of the GABA(A) receptor, also enhanced ACh release, with maximum effects of 85 and 124% above baseline, respectively. GABAA receptor antagonists potentiated the effect induced by ondansetron on ACh release, reaching a peak increase of 238% (with bicuculline) and 259% (with flumazenil) over basal levels. These results suggest an interaction of ondansetron with GABAergic neurons modulating ACh release in the rat frontal cortex in vivo. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：81 / 85

页数：5

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