Characterization of monocyte-derived dendritic cells used in immunotherapy for HIV-1-infected individuals

被引：2

作者：

da Silva, Lais Teodoro ^{[1
]}

da Silva, Wanessa Cardoso ^{[1
]}

de Almeida, Alexandre ^{[1
]}

Reis, Denise da Silva ^{[1
]}

Santllo, Bruna Tereso ^{[1
]}

Rigato, Paula Ordonhez ^{[2
]}

da Silva Duarte, Alberto Jose ^{[1
]}

Oshiro, Telma Miyuki ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Lab Invest Dermatol & Imunodeficiencias, BR-05403903 Sao Paulo, SP, Brazil

[2] Adolfo Lutz Inst, BR-01246000 Sao Paulo, SP, Brazil

来源：

IMMUNOTHERAPY | 2018年 / 10卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

dendritic cells; HIV/AIDS; immunotherapy; CHRONIC HIV-1 INFECTION; CD8(+) T-CELLS; ANTIRETROVIRAL THERAPY; TREATMENT INTERRUPTION; AUTOLOGOUS HIV-1; RESPONSES; RNA; IMMUNIZATION; VACCINATION; MIGRATION;

D O I：

10.2217/imt-2017-0165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aims: A therapeutic vaccine based on monocyte-derived dendritic cells (MDDCs) has been shown to represent a promising strategy for the treatment of cancer and viral infections. Here, we characterized the MDDCs used as an immunogen in a clinical trial for an anti-HIV-1 therapeutic vaccine. Patients & Methods: Monocytes obtained from 17 HIV-infected individuals were differentiated into MDDCs and, after loading with autologous HIV, the cells were characterized concerning surface molecule expression, migratory and phagocytosis capacity, cytokine production and the induction of an effective cell-mediated immune response. Results: The MDDCs were able to induce antigen-specific responses in autologous CD4+ and CD8+ T lymphocytes. Conclusions: Despite a large interindividual variability, the results suggested that MDDCs present the potential to promote immune responses in vaccinated patients.

引用

页码：871 / 885

页数：15

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