In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

被引：185
作者：
Ramage, G
VandeWalle, K
Bachmann, SP
Wickes, BL
López-Ribot, JL
机构：
[1] Univ Texas, Hlth Sci Ctr, Div Infect Dis, Dept Med,S Texas Ctr Biol Med, San Antonio, TX 78245 USA
[2] Univ Texas, Hlth Sci Ctr, Dept Microbiol, San Antonio, TX 78245 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 11期
关键词：
D O I：
10.1128/AAC.46.11.3634-3636.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with greater than or equal to99% killing at physiological concentrations.
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页码：3634 / 3636
页数：3
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