Parity and the risk of incident dementia: a COSMIC study

被引：26

作者：

Bae, J. B. ^{[1
,2
]}

Lipnicki, D. M. ^{[3
]}

Han, J. W. ^{[1
,2
]}

Sachdev, P. S. ^{[3
,4
]}

Kim, T. H. ^{[5
]}

Kwak, K. P. ^{[6
]}

Kim, B. J. ^{[7
]}

Kim, S. G. ^{[8
]}

Kim, J. L. ^{[9
]}

Moon, S. W. ^{[10
,11
]}

Park, J. H. ^{[12
]}

Ryu, S-H ^{[13
,14
]}

Youn, J. C. ^{[15
]}

Lee, D. Y. ^{[2
,16
]}

Lee, D. W. ^{[17
]}

Lee, S. B. ^{[18
]}

Lee, J. J. ^{[18
]}

Jhoo, J. H. ^{[19
]}

Skoog, I ^{[20
]}

Najar, J. ^{[20
]}

Sterner, T. R. ^{[20
]}

Scarmeas, N. ^{[21
,22
]}

Yannakoulia, M. ^{[23
]}

Dardiotis, E. ^{[24
]}

Riedel-Heller, S. ^{[25
]}

Roehr, S. ^{[25
]}

Pabst, A. ^{[25
]}

Ding, D. ^{[26
,27
]}

Zhao, Q. ^{[26
,27
]}

Liang, X. ^{[26
,27
]}

Lobo, A. ^{[28
,29
,30
]}

De-la-Camara, C. ^{[28
,29
,30
]}

Lobo, E. ^{[28
,29
,30
]}

Kim, K. W. ^{[1
,2
,31
]}

机构：

[1] Seoul Natl Univ, Dept Neuropsychiat, Bundang Hosp, Seongnam, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[3] Univ New South Wales, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

[4] Univ New South Wales, Dementia Collaborat Res Ctr, Sydney, NSW, Australia

[5] Yonsei Univ, Dept Psychiat, Wonju Severance Christian Hosp, Wonju, South Korea

[6] Dongguk Univ, Dept Psychiat, Gyeongju Hosp, Gyeongju, South Korea

[7] Gyeongsang Natl Univ, Sch Med, Dept Psychiat, Jinju, South Korea

[8] Soonchunhyang Univ, Dept Neuropsychiat, Bucheon Hosp, Bucheon, South Korea

[9] Chungnam Natl Univ, Sch Med, Dept Psychiat, Daejeon, South Korea

[10] Konkuk Univ, Sch Med, Dept Psychiat, Chungju, South Korea

[11] Konkuk Univ, Chungju Hosp, Chungju, South Korea

[12] Jeju Natl Univ Hosp, Dept Neuropsychiat, Jeju, South Korea

[13] Konkuk Univ, Sch Med, Dept Psychiat, Seoul, South Korea

[14] Konkuk Univ, Med Ctr, Seoul, South Korea

[15] Kyunggi Prov Hosp Elderly, Dept Neuropsychiat, Yongin, South Korea

[16] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea

[17] Inje Univ, Dept Neuropsychiat, Sanggye Paik Hosp, Seoul, South Korea

[18] Dankook Univ Hosp, Dept Psychiat, Cheonan, South Korea

[19] Kangwon Natl Univ Hosp, Dept Neuropsychiat, Chunchon, South Korea

[20] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci Physiol, Dept Psychiat & Neurochem,Ctr Ageing & Hlth AGECA, Gothenburg, Sweden

[21] Natl & Kapodistrian Univ Athens, Aiginit Hosp, Med Sch, Dept Neurol 1, Athens, Greece

[22] Columbia Univ, Dept Neurol, New York, NY USA

[23] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece

[24] Univ Thessaly, Univ Hosp Larissa, Neurol Dept, Larisa, Greece

[25] Univ Leipzig, Med Fac, Inst Social Med Occupat Hlth & Publ Hlth ISAP, Leipzig, Germany

[26] Fudan Univ, Huashan Hosp, Inst Neurol, Shanghai, Peoples R China

[27] Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai, Peoples R China

[28] Univ Zaragoza, Dept Med & Psychiat, Zaragoza, Spain

[29] Inst Invest Sanitaria Aragon, Zaragoza, Spain

[30] Inst Salud Carlos III, Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain

[31] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea

来源：

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES | 2020年 / 29卷

基金：

中国国家自然科学基金; 英国医学研究理事会; 瑞典研究理事会; 美国国家卫生研究院;

关键词：

Dementia; geriatric psychiatry; risk factors; women; ALZHEIMERS-DISEASE; GRAND MULTIPARITY; WOMEN; POPULATION; ATHEROSCLEROSIS; ASSOCIATION; CHOLESTEROL; PREVALENCE; MORTALITY; ESTRADIOL;

D O I：

10.1017/S2045796020000876

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aims. To investigate the association between parity and the risk of incident dementia in women. Methods. We pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)). Results. Of 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 +/- 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02-1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1-4 parities (HR = 1.30, 95% CI = 1.02-1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02-1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00-2.55), but the risk of AD was not significantly associated with parity. Conclusions. Grand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high.

引用

页数：7

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