Foundation review: α7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and mesothelioma?

被引：41

作者：

Paleari, Laura ^{[1
]}

Cesario, Alfredo ^{[2
,3
]}

Fini, Massimo ^{[4
]}

Russo, Patrizia ^{[1
]}

机构：

[1] Natl Inst Canc Res, Lung Canc Unit, Genoa, Italy

[2] Catholic Univ, Thorac Surg Unit, Rome, Italy

[3] CDC San Raffaele Velletri Rome, Rome, Italy

[4] IRCCS San Raffaele, Rome, Italy

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 17-18期

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTOR; CELL LUNG-CARCINOMA; BRONCHIAL EPITHELIAL-CELLS; AFFECT GROWTH-REGULATION; CRYSTAL-STRUCTURE; ALPHA-NEUROTOXINS; SUSCEPTIBILITY LOCUS; MEDIATED ACTIVATION; CIGARETTE-SMOKING; CA2+ PERMEABILITY;

D O I：

10.1016/j.drudis.2009.06.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Of the human solid cancers, Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM) display a natural history supporting the concept that they develop from multiple preneoplastic pathways. Recently, new evidence suggested that nicotinic Acetylcholine Receptors (nAChRs) play a significant role in lung cancer predisposition and natural history. This review is based on some translational research aimed at evaluating the potential therapeutic effect of nAChR antagon on NSCLC and MPM. The background and rationale of this approach are based on the experimental observations that: (a) NSCLC and MPM cells express nAChRs and (b) the activation of these receptors by agonists, namely nicotine, inhibits apoptosis, whereas receptor antagonists have a pro-apoptotic effect.

引用

页码：822 / 836

页数：15

共 136 条

[1] Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 [J].