Thermo-Induced Free-Radical Cleavage of Enaminone C=C Double Bond for α-Acyloxyl Ketone Synthesis

被引：19

作者：

Tian, Lihong ^{[1
]}

Guo, Yanhui ^{[1
]}

Wei, Li ^{[1
]}

Wan, Jie-Ping ^{[1
]}

Sheng, Shouri ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

enaminones; cleavage reactions; free radicals; peroxides; SET; CATALYTIC-OXIDATION; 1,2-ACYL MIGRATION; COUPLING REACTIONS; ALKENE OXIDATION; CARBON; BENZOYLOXYLATION; PYRIDINES; ALDEHYDES; ACCESS; ESTERS;

D O I：

10.1002/ajoc.201900373

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cleavage on the C=C double bonds of N,N-dimethyl enaminones is initiated by a thermo-induced free-radical transformation, enabling the chemo-selective synthesis of alpha-acyloxyl ketones. The Mn(II)-assisted single-electron transfer (SET) from the free radical intermediate resulting from addition of the carboxyl radical to enaminone is the key process in modulating the expected reaction pathway.

引用

页码：1484 / 1489

页数：6

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