共 48 条
A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
被引:654
作者:
Teunissen, C. E.
[1
]
Petzold, A.
[2
]
Bennett, J. L.
[3
,4
]
Berven, F. S.
[5
]
Brundin, L.
[6
]
Comabella, M.
[7
]
Franciotta, D.
[8
]
Frederiksen, J. L.
[9
]
Fleming, J. O.
[10
]
Furlan, R.
[11
]
Hintzen, R. Q.
[12
]
Hughes, S. G.
[13
]
Johnson, M. H.
[14
]
Krasulova, E.
[15
]
Kuhle, J.
[16
]
Magnone, M. C.
[17
]
Rajda, C.
[18
]
Rejdak, K.
[19
,20
]
Schmidt, H. K.
[21
]
van Pesch, V.
[22
]
Waubant, E.
[23
]
Wolf, C.
[24
]
Giovannoni, G.
Hemmer, B.
[25
]
Tumani, H.
[26
]
Deisenhammer, F.
[27
]
机构:
[1] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Neurol Lab Clin Chem,FdG, NL-1007 MB Amsterdam, Netherlands
[2] UCL Inst Neurol, Dept Neuroimmunol, London, England
[3] Univ Colorado Denver, Dept Neurol, Aurora, CO USA
[4] Univ Colorado Denver, Dept Ophthalmol, Aurora, CO USA
[5] Univ Bergen, Inst Med, N-5020 Bergen, Norway
[6] Karolinska Univ Hosp, Div Neurol, Dept Clin Neurosci, Stockholm, Sweden
[7] Hosp Univ Vall Hebron, Unitat Neuroimmunol Clin, CEM Cat, Barcelona, Spain
[8] Univ Pavia, Neurol Inst C Mondino, IRCCS, Lab Neuroimmunol, I-27100 Pavia, Italy
[9] Univ Copenhagen, Glostrup Hosp, Glostrup, Denmark
[10] Univ Wisconsin, Dept Neurol, Madison, WI 53706 USA
[11] Ist Sci San Raffaele, Clin Neuroimmunol Unit, Inst Expt Neurol, I-20132 Milan, Italy
[12] Erasmus MC, Rotterdam, Netherlands
[13] Biogen Idec Inc, Med Res, Maidenhead, Berks, England
[14] Leeds Teaching Hosp NHS Trust, Dept Neurol, Leeds, W Yorkshire, England
[15] Charles Univ Prague, Dept Neurol, Fac Med 1, Prague, Czech Republic
[16] Univ Basel, Univ Hosp, CH-4003 Basel, Switzerland
[17] F Hoffmann La Roche Pharma, Basel, Switzerland
[18] Univ Szeged, Dept Neurol, Szeged, Hungary
[19] Med Univ Lublin, Dept Neurol, Warsaw, Poland
[20] Polish Acad Sci, Med Res Ctr, Dept Expt Pharmacol, Warsaw, Poland
[21] Accelerated Cure Project Multiple Sclerosis, Waltham, MA USA
[22] Clin Univ St Luc, Dept Neurol, B-1200 Brussels, Belgium
[23] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[24] UCB Pharma SA, Clin Dev, Braine Lalleud, Belgium
[25] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-8000 Munich, Germany
[26] Univ Hosp Ulm, Dept Neurol, Ulm, Germany
[27] Innsbruck Med Univ, Dept Clin Neurol, Innsbruck, Austria
来源:
基金:
英国医学研究理事会;
关键词:
MULTIPLE-SCLEROSIS PATIENTS;
AMYLOID-BETA PEPTIDES;
STATUS SCALE EDSS;
LUMBAR PUNCTURE;
DIAGNOSTIC-CRITERIA;
MASS-SPECTROMETRY;
DISABILITY;
DISEASE;
BLOOD;
SERUM;
D O I:
10.1212/WNL.0b013e3181c47cc2
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease. Neurology (R) 2009; 73: 1914-1922
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页码:1914 / 1922
页数:9
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