Pre-metastatic niches: organ-specific homes for metastases

被引：1384

作者：

Peinado, Hector ^{[1
,2
,3
]}

Zhang, Haiying ^{[1
,2
]}

Matei, Irina R. ^{[1
,2
]}

Costa-Silva, Bruno ^{[1
,2
,4
]}

Hoshino, Ayuko ^{[1
,2
]}

Rodrigues, Goncalo ^{[1
,2
,5
]}

Psaila, Bethan ^{[6
]}

Kaplan, Rosandra N. ^{[7
]}

Bromberg, Jacqueline F. ^{[8
]}

Kang, Yibin ^{[9
,10
]}

Bissell, Mina J. ^{[11
]}

Cox, Thomas R. ^{[12
,13
]}

Giaccia, Amato J. ^{[14
]}

Erler, Janine T. ^{[15
]}

Hiratsuka, Sachie ^{[16
]}

Ghajar, Cyrus M. ^{[17
]}

Lyden, David ^{[1
,2
,18
]}

机构：

[1] Weill Cornell Med, Meyer Canc Ctr, Drukier Inst Childrens Hlth, Dept Pediat,Childrens Canc & Blood Fdn Labs, New York, NY 10021 USA

[2] Weill Cornell Med, Meyer Canc Ctr, Drukier Inst Childrens Hlth, Dept Cell & Dev Biol,Childrens Canc & Blood Fdn L, New York, NY 10021 USA

[3] Spanish Natl Canc Res Ctr CNIO, Dept Mol Oncol, Microenvironm & Metastasis Grp, Madrid 28029, Spain

[4] Champalimaud Ctr Unknown, Syst Oncol Grp, Champalimaud Res, Ave Brasilia,Doca Pedroucos, P-1400038 Lisbon, Portugal

[5] Univ Porto, Abel Salazar Biomed Sci Inst, Grad Program Areas Basic & Appl Biol, P-4099003 Oporto, Portugal

[6] Imperial Coll London, Hammersmith Hosp, Ctr Haematol, Dept Med, London W12 0HS, England

[7] NCI, Ctr Canc Res, Pediat Oncol Branch, NIH, Bldg 10 Hatfield CRC,Room 1-3940, Bethesda, MD 20892 USA

[8] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[9] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[10] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[11] Lawrence Berkeley Natl Lab, Biol Syst & Engn Div, Berkeley, CA 94720 USA

[12] Univ New South Wales, Fac Med, Garvan Inst Med Res, Sydney, NSW 2010, Australia

[13] Univ New South Wales, Fac Med, Kinghorn Canc Ctr, St Vincents Clin Sch,Canc Div, Sydney, NSW 2010, Australia

[14] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

[15] Univ Copenhagen UCPH, Biotech Res & Innovat Ctr BRIC, DK-2200 Copenhagen, Denmark

[16] Tokyo Womens Med Univ, Sch Med, Dept Pharmacol, 8-1 Kawada Cho, Tokyo 1628666, Japan

[17] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Translat Res Program, Seattle, WA 98109 USA

[18] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 05期

基金：

英国惠康基金;

关键词：

BREAST-CANCER METASTASIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR BARRIER PERMEABILITY; GROWTH-FACTOR RECEPTOR-1; C CHEMOKINE RECEPTOR-5; COLLAGEN CROSS-LINKING; SENTINEL LYMPH-NODES; E-SELECTIN LIGAND-1; PROSTATE-CANCER; BONE-MARROW;

D O I：

10.1038/nrc.2017.6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

引用

页码：302 / 317

页数：16

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