Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis

被引：98

作者：

Halliwell, Barry ^{[1
]}

Cheah, Irwin K. ^{[1
]}

Drum, Chester L. ^{[2
,3
,4
]}

机构：

[1] Natl Univ Singapore, Dept Biochem, Singapore 117548, Singapore

[2] Natl Univ Hlth Syst, Cardiovasc Res Inst, Singapore, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore

[4] Immunos, Biomed Grove 8A, Translat Lab Genet Med, Level 5, Singapore 138648, Singapore

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2016年 / 470卷 / 02期

基金：

英国医学研究理事会;

关键词：

Reactive oxygen species; Antioxidant; Ergothioneine; Adaptation; OCTN1; Mushrooms; ORGANIC CATION TRANSPORTER; RED-BLOOD-CELLS; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; CROHNS-DISEASE; AMINO-ACID; GENETIC-VARIATIONS; 503F VARIANT; SLC22A5; GENE; HIGH-FAT;

D O I：

10.1016/j.bbrc.2015.12.124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ergothioneine (ET) is a diet-derived, thiolated derivative of histidine with antioxidant properties. Although ET is produced only by certain fungi and bacteria, it can be found at high concentrations in certain human and animal tissues and is absorbed through a specific, high affinity transporter (OCTN1). In liver, heart, joint and intestinal injury, elevated ET concentrations have been observed in injured tissues. The physiological role of ET remains unclear. We thus review current literature to generate a specific hypothesis: that the accumulation of ET in vivo is an adaptive mechanism, involving the regulated uptake and concentration of an exogenous natural compound to minimize oxidative damage. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：245 / 250

页数：6

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