Ozanimod Maintenance Therapy After Cyclosporine Induction in Acute Severe Ulcerative Colitis

被引:10
作者
Cohen, Nathaniel A. [1 ]
Dalal, Sushila R. [1 ]
Choi, David [1 ]
Rubin, David T. [1 ]
机构
[1] Univ Chicago Med, Inflammatory Bowel Dis Ctr, Chicago, IL 60637 USA
关键词
INFLIXIMAB;
D O I
10.14309/crj.0000000000000832
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Ozanimod has recently received US Food and Drug Administration approval for moderate-to-severe ulcerative colitis. Treatment of acute severe colitis remains a clinical challenge, and although many patients respond to cyclosporine therapy, there remains a relative paucity of maintenance options. This case report describes the first reported, successful use of ozanimod after hospitalization for acute severe ulcerative colitis and in tandem with cyclosporine. Although a longer follow-up is required, this report shows the feasibility of ozanimod in this clinical setting.
引用
收藏
页数:4
相关论文
共 9 条
[1]   Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis [J].
Brandse, Johannan F. ;
van den Brink, Gijs R. ;
Wildenberg, Manon E. ;
van der Kleij, Desiree ;
Rispens, Theo ;
Jansen, Jeroen M. ;
Mathot, Ron A. ;
Ponsioen, Cyriel Y. ;
Lowenberg, Mark ;
D'Haens, Geert R. A. M. .
GASTROENTEROLOGY, 2015, 149 (02) :350-+
[2]   FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function [J].
Brinkmann, V ;
Cyster, JG ;
Hla, T .
AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (07) :1019-1025
[3]   Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease [J].
Christensen, Britt ;
Gibson, Peter R. ;
Micic, Dejan ;
Colman, Ruben J. ;
Goeppinger, Sarah R. ;
Kassim, Olufemi ;
Yarur, Andres ;
Weber, Christopher R. ;
Cohen, Russell D. ;
Rubin, David T. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (03) :486-493
[4]   The pattern and outcome of acute severe colitis [J].
Dinesen, Lotte C. ;
Walsh, Alissa J. ;
Protic, Marijana Nedeljkovic ;
Heap, Graham ;
Cummings, Fraser ;
Warren, Bryan F. ;
George, Bruce ;
Mortensen, Neil J. M. ;
Travis, Simon P. L. .
JOURNAL OF CROHNS & COLITIS, 2010, 4 (04) :431-437
[5]   C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease [J].
Hibi, Toshifumi ;
Sakuraba, Atsushi ;
Watanabe, Mamoru ;
Motoya, Satoshi ;
Ito, Hiroaki ;
Sato, Noriko ;
Yoshinari, Toru ;
Motegi, Kenta ;
Kinouchi, Yoshitaka ;
Takazoe, Masakazu ;
Suzuki, Yasuo ;
Matsumoto, Takayuki ;
Kawakami, Kazuhiko ;
Matsumoto, Takayuki ;
Hirata, Ichiro ;
Tanaka, Shinji ;
Ashida, Toshifumi ;
Matsui, Toshiyuki .
JOURNAL OF GASTROENTEROLOGY, 2014, 49 (02) :254-262
[6]   High C-reactive protein in Crohn's disease patients predicts nonresponse to infliximab treatment [J].
Magro, Fernando ;
Rodrigues-Pinto, Eduardo ;
Santos-Antunes, Joao ;
Vilas-Boas, Filipe ;
Lopes, Susana ;
Nunes, Amadeu ;
Camila-Dias, Claudia ;
Macedo, Guilherme .
JOURNAL OF CROHNS & COLITIS, 2014, 8 (02) :129-136
[7]   Efficacy and safety of induction therapy with calcineurin inhibitors followed by vedolizumab maintenance in 71 patients with severe steroid-refractory ulcerative colitis [J].
Ollrch, Jacob E. ;
Dwadasi, Sujaata ;
Rai, Victoria ;
Peleg, Noam ;
Normatov, Inessa ;
Israel, Amanda ;
Sossenheimer, Philip H. ;
Christensen, Britt ;
Pekow, Joel ;
Dalal, Sushila R. ;
Sakuraba, Atsushi ;
Cohen, Russell D. ;
Rubin, David T. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 51 (06) :637-643
[8]   Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis [J].
Sandborn, William J. ;
Feagan, Brian G. ;
D'Haens, Geert ;
Wolf, Douglas C. ;
Jovanovic, Igor ;
Hanauer, Stephen B. ;
Ghosh, Subrata ;
Petersen, AnnKatrin ;
Hua, Steven Y. ;
Lee, Ji Hwan ;
Charles, Lorna ;
Chitkara, Denesh ;
Usiskin, Keith ;
Colombel, Jean-Frederic ;
Laine, Loren ;
Danese, Silvio .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (14) :1280-1291
[9]   Multiple-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites and the Pharmacodynamic and Pharmacokinetic Interactions with Pseudoephedrine, a Sympathomimetic Agent, in Healthy Subjects [J].
Tran, Jonathan Q. ;
Zhang, Peijin ;
Walker, Susan ;
Ghosh, Atalanta ;
Syto, Mary ;
Wang, Xiaomin ;
Harris, Sarah ;
Palmisano, Maria .
ADVANCES IN THERAPY, 2020, 37 (12) :4944-4958