Hippocampal Neurogenesis in Conditions of Chronic Stress Induced by Sciatic Nerve Injury in the Rat

被引：14

作者：

Egorova, Evgeniia ^{[1
,2
]}

Starinets, Anna ^{[1
,2
]}

Tyrtyshnaia, Anna ^{[1
,2
]}

Ponomarenko, Arina ^{[1
,2
]}

Manzhulo, Igor ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Natl Sci Ctr Marine Biol, Far Eastern Branch, Palchevsky St 17, Vladivostok 690041, Russia

[2] Far Eastern Fed Univ, Vladivostok, Russia

来源：

CELLS TISSUES ORGANS | 2019年 / 207卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

Sciatic nerve injury; Hippocampus; PCNA; DCX; iba-1; CD86; CD163; NEUROPATHIC PAIN; ADULT NEUROGENESIS; DOCOSAHEXAENOIC ACID; MICROGLIA; EXPRESSION; MODEL; POLARIZATION; DOUBLECORTIN; BEHAVIOR; MARKERS;

D O I：

10.1159/000501236

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The dentate gyrus of the hippocampus is the primary location of adult neurogenesis, which is affected by a variety of external and internal factors, including activity of surrounding glial cells. This study concerns alterations in hippocampal neurogenesis and changes in activity of both proinflammatory and neuroprotective microglia/macrophages after sciatic nerve injury in the rat. Here, we demonstrated that the chronic pain induced by a peripheral nerve injury manifests in the hippocampus by a decrease in proliferation (PCNA+) and neurogenesis (DCX+), an increase in proinflammatory cytokines (CD86+), and a reduction in neuroprotective (CD163+) microglia/macrophages. We suggest that a pathological increase microglia/macrophage activity is the cause of neurogenesis suppression observed in chronic neuropathic pain.

引用

页码：58 / 68

页数：11

共 55 条

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