L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

被引：59
作者：
Fourcaudot, Elodie [1 ,2 ]
Gambino, Frederic [2 ]
Casassus, Guillaume [1 ]
Poulain, Bernard [2 ]
Humeau, Yann [1 ,2 ]
Luethi, Andreas [1 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, Basel, Switzerland
[2] CNRS, UPR3212, Strasbourg, France
来源：
NATURE NEUROSCIENCE | 2009年 / 12卷 / 09期
基金：
瑞士国家科学基金会; 奥地利科学基金会;
关键词：
GATED CALCIUM-CHANNELS; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; LATERAL AMYGDALA; BRAIN;
D O I：
10.1038/nn.2378
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca2+ channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC-mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.
引用
收藏
页码：1093 / 1095
页数：3
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