In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

被引:213
作者
Mezzanotte, Laura [1 ]
van 't Root, Moniek [1 ]
Karatas, Hacer [2 ]
Goun, Elena A. [2 ]
Lowik, Clemens W. G. M. [1 ]
机构
[1] Erasmus MC, Opt Mol Imaging, Dept Radiol, Rotterdam, Netherlands
[2] Swiss Fed Inst Technol Lausanne EPFL, Inst Chem Sci & Engn ISIC, Lab Bioorgan Chem & Mol Imaging, CH-1015 Lausanne, Switzerland
基金
欧盟地平线“2020”;
关键词
HYDROGEN-PEROXIDE; REPORTER MICE; CANCER-CELLS; SINGLE-CELL; LUCIFERASE; INFECTION; MODEL; RED; VISUALIZATION; PROTEINS;
D O I
10.1016/j.tibtech.2017.03.012
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
in vivo bioluminescence imaging (BLi) is an optical molecular imaging technique used to visualize molecular and cellular processes in health and diseases and to follow the fate of cells with high sensitivity using luciferase-based gene reporters. The high sensitivity of this technique arises from efficient photon production, followed by the reaction between luciferase enzymes and luciferin substrates. Novel discoveries and developments of luciferase reporters, substrates, and gene-editing techniques, and emerging fields of applications, promise a new era of deeper and more sensitive molecular imaging.
引用
收藏
页码:640 / 652
页数:13
相关论文
共 93 条
  • [1] Near infrared bioluminescence resonance energy transfer from firefly luciferase-quantum dot bionanoconjugates
    Alam, Rabeka
    Karam, Liliana M.
    Doane, Tennyson L.
    Zylstra, Joshua
    Fontaine, Danielle M.
    Branchini, Bruce R.
    Maye, Mathew M.
    [J]. NANOTECHNOLOGY, 2014, 25 (49)
  • [2] Novel multistep BRET-FRET energy transfer using nanoconjugates of firefly proteins, quantum dots, and red fluorescent proteins
    Alam, Rabeka
    Zylstra, Joshua
    Fontaine, Danielle M.
    Branchini, Bruce R.
    Maye, Mathew M.
    [J]. NANOSCALE, 2013, 5 (12) : 5303 - 5306
  • [3] In vivo bioluminescence and reflectance imaging of multiple organs in bioluminescence reporter mice by bundled-fiber-coupled microscopy
    Ando, Yoriko
    Sakurai, Takashi
    Koida, Kowa
    Tei, Hajime
    Hida, Akiko
    Nakao, Kazuki
    Natsume, Mistuo
    Numano, Rika
    [J]. BIOMEDICAL OPTICS EXPRESS, 2016, 7 (03): : 963 - 978
  • [4] Imaging Ca2+ activity in mammalian cells and zebrafish with a novel red-emitting aequorin variant
    Bakayan, Adil
    Domingo, Beatriz
    Miyawaki, Atsushi
    Llopis, Juan
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2015, 467 (09): : 2031 - 2042
  • [5] CLONING OF THE LUCIFERASE STRUCTURAL GENES FROM VIBRIO-HARVEYI AND EXPRESSION OF BIOLUMINESCENCE IN ESCHERICHIA-COLI
    BALDWIN, TO
    BERENDS, T
    BUNCH, TA
    HOLZMAN, TF
    RAUSCH, SK
    SHAMANSKY, L
    TREAT, ML
    ZIEGLER, MM
    [J]. BIOCHEMISTRY, 1984, 23 (16) : 3663 - 3667
  • [6] Thermostable red and green light-producing firefly luciferase mutants for bioluminescent reporter applications
    Branchini, Bruce R.
    Ablamsky, Danielle M.
    Murtiashaw, Martha H.
    Uzasci, Lerna
    Fraga, Hugo
    Southworth, Tara L.
    [J]. ANALYTICAL BIOCHEMISTRY, 2007, 361 (02) : 253 - 262
  • [7] An enhanced chimeric firefly luciferase-inspired enzyme for ATP detection and bioluminescence reporter and imaging applications
    Branchini, Bruce R.
    Southworth, Tara L.
    Fontaine, Danielle M.
    Kohrt, Dawn
    Talukder, Munya
    Michelini, Elisa
    Cevenini, Luca
    Roda, Aldo
    Grossel, Martha J.
    [J]. ANALYTICAL BIOCHEMISTRY, 2015, 484 : 148 - 153
  • [8] Red-emitting luciferases for bioluminescence reporter and imaging applications
    Branchini, Bruce R.
    Ablamsky, Danielle M.
    Davis, Audrey L.
    Southworth, Tara L.
    Butler, Braeden
    Fan, Frank
    Jathoul, Amit P.
    Pule, Martin A.
    [J]. ANALYTICAL BIOCHEMISTRY, 2010, 396 (02) : 290 - 297
  • [9] In vivo imaging of NF-κB activity
    Carlsen, H
    Moskaug, JO
    Fromm, SH
    Blomhoff, R
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (03) : 1441 - 1446
  • [10] Genome Engineering with Targetable Nucleases
    Carroll, Dana
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83, 2014, 83 : 409 - 439