Pharmacology and safety of tofacitinib in ulcerative colitis

被引：45

作者：

Lopez-Sanroman, Antonio ^{[1
]}

Esplugues, Juan, V ^{[2
]}

Domenech, Eugeni ^{[3
,4
]}

机构：

[1] Hosp Univ Ramon Y Cajal, Serv Gastroenterol & Hepatol, Madrid, Spain

[2] Univ Valencia, Fac Med, Dept Farmacol, Unidad Farmacol Digest & Inflamatoria, Valencia, Spain

[3] Hosp Badalona Germans Trias & Pujol, Serv Gastroenterol & Hepatol, Badalona, Catalunya, Spain

[4] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2021年 / 44卷 / 01期

关键词：

Tofacitinib; Safety; Pharmacology; Ulcerative colitis; Janus kinase; JAK; JANUS KINASE INHIBITOR; MAINTENANCE THERAPY; JAK INHIBITION; PHARMACOKINETICS; PHARMACOTHERAPY; PREVENTION; INDUCTION; IMMUNE; RISK;

D O I：

10.1016/j.gastrohep.2020.04.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

YY The use of Janus kinase (JAK) inhibitors is a new approach in the therapy of inflammatory diseases with immune base. Tofacitinib is one of these inhibitors targeting JAK1 and JAK3, and its efficacy has been demonstrated in the treatment of moderate to severe ulcerative colitis (UC). It is a small synthetic molecule administered orally, with a fast bioavailability and elimination rate, predictable pharmacokinetics and lack of immunogenicity, which are convenient characteristics for both efficacy and safety. This article reviews the pharmacological characteristics of tofacitinib and its safety profile. (C) 2020 The Authors. Published by Elsevier Espana, S.L.U.

引用

页码：39 / 48

页数：10

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