Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules

被引：11

作者：

Bi, Wei ^{[1
,4
]}

Bi, Yue ^{[4
]}

Gao, Xiang ^{[2
]}

Yan, Xin ^{[2
]}

Zhang, Yanrong ^{[4
]}

Xue, Ping ^{[4
]}

Bammert, Catherine E. ^{[3
]}

Legalley, Thomas D. ^{[6
]}

Gibson, K. Michael ^{[5
]}

Bi, Lanrong ^{[2
]}

Wang, Jia-Xiang ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Med, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[2] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[3] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA

[4] HeBei Med Univ, Hosp 2, Shijiazhuang 050000, Hebei, Peoples R China

[5] Washington State Univ, Coll Pharm, Sect Expt & Syst Pharmacol, Spokane, WA 99202 USA

[6] Marquette Gen Heart & Vasc Inst, Marquette, MI 49855 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 08期

基金：

美国国家科学基金会;

关键词：

Anti-inflammatory activity; Analgesic activity; Free radical scavenging activity; Kyotorphin-nitroxide hybrid molecules; Ischemia/reperfusion injury; MITOCHONDRIA-TARGETED ANTIOXIDANTS; ACUTE LIMB ISCHEMIA/REPERFUSION; DUAL-ACTING AGENTS; CHEMOPREVENTION AGENTS; FLUORESCENT-PROBES; OXIDATIVE STRESS; INJURY; ISCHEMIA; DESIGN; RATS;

D O I：

10.1016/j.bmcl.2016.02.086

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury, cardiovascular disorders and neurodegenerative diseases. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel kyotorphin-nitroxide hybrid molecules, and examined their free radical scavenging activities, in addition to their anti-inflammatory and analgesic activities. We have further characterized these compounds in a simulated I/R cellular model. Our findings suggest that the protective effects of kyotorphin-nitroxides partially reside in maintaining optimal mitochondrial function. Published by Elsevier Ltd.

引用

页码：2005 / 2013

页数：9

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