Complexes of platinum(II) or palladium(II) with 1,10-phenanthroline and amino acids

被引：87

作者：

Jin, VX ^{[1
]}

Ranford, JD

机构：

[1] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada

[2] Natl Univ Singapore, Dept Chem, Singapore 119270, Singapore

来源：

INORGANICA CHIMICA ACTA | 2000年 / 304卷 / 01期

关键词：

platinum complexes; palladium complexes; phenanthroline complexes; amino acid complexes;

D O I：

10.1016/S0020-1693(00)00061-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The amino acids complexes of [Pt(phen)(AA)]NO3. xH(2)O and [Pd(phen)(AA)]NO3. xH(2)O have been prepared by the interaction of palladium and platinum complexes, [Pt(phen)Cl-2] and rPd(phen)Cl-2] with salts of amino acids in methanol and characterized by H-1 NMR and IR spectroscopy which confirmed the formation of a very large variety of compounds with ligand in a simple way (bidentate). All of these new compounds have been isolated and tested for cytotoxicity on Molt-4, a human leukaemia cell line. The IC50 values of [Pt(phen)(Pro)]Cl . 2H(2)O and [Pd(phen)(Asp)]Cl . 1.5H(2)O are 9.8 and 7.31 mu M, respectively, exhibiting a significant activity which is close to cis-[PtCl2(NH3)(2). (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：38 / 44

页数：7

共 14 条

[1]

Angelici R. J., 1969, SYNTHESIS TECHNIQUE, P17

[2] S,O-CHELATION VERSUS S,N-CHELATION IN THE REACTIONS OF THE CIS-DIAMMINEDIAQUAPLATINUM(II) CATION WITH METHIONINE AND S-METHYLCYSTEINE [J].