Comparison of Efficacy of Teriparatide (Parathyroid Hormone 1-34) Alone and in Combination with Zoledronic Acid for Osteoporosis in Postmenopausal Women

被引：3

作者：

Wei, Kang ^{[1
]}

Qu, Yuxing ^{[1
]}

Gao, Yi ^{[1
]}

Ma, Yong ^{[2
]}

机构：

[1] Nanjing Univ Chinese Med, Changzhou Tradit Chinese Med Hosp, Dept Orthopad 1, Nanjing, Peoples R China

[2] Nanjing Univ Chinese Med, Clin Med Coll 1, Dept Orthoped & Traumatol, Nanjing 210023, Peoples R China

来源：

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN | 2021年 / 31卷 / 02期

关键词：

Teriparatide ( parathyroid hormone 1-34; Zoledronic acid (ZA); Postmenopausal; Osteoporosis; Bone mineral density (BMD);

D O I：

10.29271/jcpsp.2021.02.240

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this study was to compare the efficacy of teriparatide (parathyroid hormone 1-34) alone and in combination with zoledronic acid (ZA) for the treatment of osteoporosis in postmenopausal women. Ninety-six patients were randomly equally divided into Groups A (n=48) and B (n=48). Group A was given parathyroid hormone 1-34 alone. Group B was treated with parathyroid hormone 1-34 plus ZA. Visual analogue scale (VAS) score, bone mineral density(BMD), serum osteopontin (OPN), and C-terminal cross-linking telopeptide of type I collagen (S-CTX) etc. were compared. After 6 months of treatment, VAS score, serum OPN and S-CTX levels in Group B were significantly lower than those in Group A (p=0.001, p<0.001 and p<0.001, respectively); and BMD values of lumbar vertebrae L2-4, femoral neck and total hip bone in Group B were higher than those of Group A (p=0.002, p=0.028 and p<0.001, respectively). In conclusion, parathyroid hormone 1-34 plus ZA is more effective than parathyroid hormone 1-34 alone in treating post postmenopausal osteoporosis.

引用

页码：240 / 242

页数：3

共 6 条

[1] Rapid protein kinase A-mediated activation of cyclic AMP-phosphodiesterase by parathyroid hormone in UMR-106 osteoblast-like cells [J].